Table of Contents
Where in the protein is YAP phosphorylated?
In this report we show that YAP is regulated by the Hippo pathway and may play an important role in mediating cell contact inhibition. YAP is phosphorylated and inhibited by the Lats tumor suppressor, and this phosphorylation results in its association with 14–3–3 and cytoplasmic localization.
What is YAP gene?
YAP1 (yes-associated protein 1), also known as YAP or YAP65, is a protein that acts as a transcription coregulator that promotes transcription of genes involved in cellular proliferation and suppressing apoptotic genes.
What is YAP pathway?
The Hippo-YAP pathway relays diversified extracellular and intracellular signals, including cell density, cell polarity, mechanical cues, ligands of G-protein-coupled receptors, cellular energy status, and orchestrates cell proliferation, survival, apoptosis, and differentiation and stemness.
What is the difference between YAP and TAZ?
Biochemically, the nuclear translocation and TEAD binding of YAP and TAZ are similar. However, YAP protein levels are significantly higher than that of TAZ in HEK293 cells; therefore, we posit that the difference in YAP and TAZ protein levels may contribute to their functional differences in these cells.
How is YAP activated?
Stimulation of PAR by agonist peptides activates YAP/TAZ by inducing dephosphorylation and nuclear localization. PAR1 acts through G12/13, Rho, Lats1/2, and YAP/TAZ to stimulate gene expression, cell migration, and cell invasion.
Is YAP a transcription factor?
Abstract. Yes-associated protein (YAP) is a potent transcription coactivator acting via binding to the TEAD transcription factor, and plays a critical role in organ size regulation. YAP is phosphorylated and inhibited by the Lats kinase, a key component of the Hippo tumor suppressor pathway.
Is YAP a protein?
Yes-associated protein (YAP or YAP1) is an oncoprotein encoded by the YAP gene in the human chromosome 11q22 (1). YAP is one of the downstream proteins in the Hippo signaling pathway (1).
What is Taz in YAP Taz?
Hippo pathway negatively regulates the activity of transcriptional co-activators, Yes-associated protein 1 (YAP) and Transcriptional coactivator with PDZ-binding motif (TAZ); both YAP and TAZ are orthologs of Drosophila Yorkie [Yki]. YAP and TAZ are transcriptional coactivators, do not have DNA binding capacity.