Table of Contents
What are contraindications to metformin?
The authors identified the following potential contraindications or cautions to metformin therapy: (1) renal impairment, defined as a plasma creatinine level greater than 1.4 mg per dL (120 μmol per L) or dipstick-positive proteinuria, (2) cardiac failure, (3) chronic hepatic dysfunction, (4) significant chronic …
What should you not take with Glucophage?
Other things to avoid while on metformin
- diuretics, such as acetazolamide.
- corticosteroids, such as prednisone.
- blood pressure medication, such as amlodipine (Norvasc)
- anticonvulsants, such as topiramate (Topamax) and zonisamide (Zonegran)
- oral contraceptives.
- antipsychotic drugs, such as chlorpromazine.
What drugs interact with Glucophage?
Most frequently checked interactions
- amlodipine.
- aspirin.
- Aspirin Low Strength (aspirin)
- atorvastatin.
- Crestor (rosuvastatin)
- Cymbalta (duloxetine)
- gabapentin.
- hydrochlorothiazide.
What is the difference between Glucophage and Glucophage XR?
Glucophage and Glucophage XR (metformin hydrochloride) are oral antihyperglycemic drugs used to treat type 2 diabetes. Glucophage is available as tablets while Glucophage XR is available as extended-release tablets.
Why was Glucophage XR discontinued?
Issues Voluntary Nationwide Recall of Metformin HCl Extended Release Tablets, USP 500 mg, Due to N-Nitrosodimethylamine (NDMA) Content Above the Acceptable Daily Intake (ADI) Limit.
Why is metformin XR taken at night?
If you’re taking extended-release metformin, you should take your dose once daily at night, with your last meal of the day. Doing so allows the drug to work properly in reducing your blood sugar level.
Is it safe to take Glucophage XR?
Metformin ER (Glucophage XR) can raise the risk of low blood sugar when used with these medications. Make sure you check your blood sugar regularly whenever you start new diabetes medications or have a change in dose. Very low blood sugar can be life-threatening.
Is Glucophage XR banned?
The Glucophage XR brand name has been discontinued in the U.S. If generic versions of this product have been approved by the FDA, there may be generic equivalents available.
Can I take metformin XR in the morning?
Metformin alone: At first, 500 milligrams (mg) two times a day taken with the morning and evening meals, or 850 mg a day taken with the morning meal. Your doctor may increase your dose if needed until your blood sugar is controlled.
What is the best time to take Glucophage XR?
The recommended starting dose of GLUCOPHAGE XR is 500 mg orally once daily with the evening meal. Increase the dose in increments of 500 mg weekly on the basis of glycemic control and tolerability, up to a maximum of 2000 mg once daily with the evening meal.
Is Glucophage XR contraindicated in patients with low EGFR?
GLUCOPHAGE/GLUCOPHAGE XR is contraindicated in patients with an eGFR less than 30 mL/min/1.73 m 2 [see CONTRAINDICATIONS ]. Initiation of GLUCOPHAGE/GLUCOPHAGE XR is not recommended in patients with eGFR between 30-45 mL/min/1.73 m 2.
What are the side effects of Glucophage and Glucophage XR?
What are the side effects of GLUCOPHAGE and GLUCOPHAGE XR? Lactic acidosis. Metformin, the active ingredient in GLUCOPHAGE and GLUCOPHAGE XR, can cause a rare but serious condition called lactic acidosis (a buildup of an acid in the blood) that can cause death.
Can you take metformin with Glucophage XR?
Use of metformin in patients with hepatic impairment has been associated with some cases of lactic acidosis. Glucophage/Glucophage XR is not recommended in patients with hepatic impairment [see Warnings and Precautions (5.1)].
What is the contraindication for glomerular filtration rate XR?
GLUCOPHAGE/GLUCOPHAGE XR is contraindicated in severe renal impairment, patients with an estimated glomerular filtration rate (eGFR) below 30 mL/min/1.73 m 2 [see DOSAGE AND ADMINISTRATION, CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS, and CLINICAL PHARMACOLOGY ].