Table of Contents
What is msp1 gene?
Background. The merozoite surface protein 1 (msp1) is one of the most studied vaccine candidate genes in mammalian Plasmodium spp. to have been used for investigations of epidemiology, population structures, and immunity to infections.
What is malaria type 4?
4. Plasmodium falciparum (P.f.) – The largest number of malaria-related deaths are caused by this type, which is found in South East Asia, South America, and Africa. Symptoms include dizziness, muscle ache, fatigue, abdominal pain, sore back, seizures, nausea, vomiting, fever, headache, etc.
How is filariasis detected?
The standard method for diagnosing active infection is the identification of microfilariae in a blood smear by microscopic examination. The microfilariae that cause lymphatic filariasis circulate in the blood at night (called nocturnal periodicity).
Is Plasmodium falciparum high in MSP1 and MSP2 alleles?
Our study showed high genetic diversity and allelic frequencies of msp1 and msp2 in Plasmodium falciparum isolates from symptomatic malaria patients in Bobo-Dioulasso. Despite substantial efforts to eliminate or control malaria, it remains the leading cause of morbidity and mortality in the world [ 1 ].
Is MSP1 involved in the biology of the host parasite interface?
This article reviews the role of the MSP1 complex in the biology of the host parasite interface with a focus on MSP7 and related proteins that are coded by gene families in each of the different Plasmodium spp. Copyright 2010 Australian Society for Parasitology Inc. Published by Elsevier Ltd.
Is the dominance of the K1 allelic family associated with malaria?
In previous studies, the dominance of K1 allelic family has been associated with severe malaria [ 32, 33] and also with asymptomatic malaria [ 34, 35 ]. Our study reported high genetic diversity with 21 and 25 genotypes for msp1 and msp2, respectively, in parasites circulating in the southwest of Burkina Faso.
What happens to MSP1 during invasion of the new red cell?
During invasion of the new red cell most of the MSP1 molecule is shed from the parasite surface except for a small C-terminal fragment which can be detected in ring stages. Analysis of the structure of this fragment suggests that it contains two growth factor-like domains that may have a functional role.