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Can nifedipine cause gingival hyperplasia?
The principal action of nifedipine is to inhibit the influx of extracellular calcium ions across the membranes of cardiac and vascular smooth muscle cells, without changing serum calcium concentration (1). One of the side effects of this drug is gingival hyperplasia which was first described in 1984 by Lederman (2).
Can nifedipine cause gingivitis?
Nifedipine is one of the commonest antihypertensive drugs (calcium channel blockers) used to treat hypertension and some forms of angina. Though it has various side effects, gingival enlargement is the most attended side effect which is of great importance in dentistry.
What are the symptoms of gingival hyperplasia?
Gingival hyperplasia symptoms
- tender gums.
- inflammation.
- pain.
- bad breath.
- plaque buildup on teeth.
How is drug-induced gingival enlargement treated?
The most effective treatment of drug-related gingival enlargement is withdrawal or substitution of medication. When this treatment approach is taken, it may take from 1 to 8 weeks for resolution of gingival lesions.
Why do calcium channel blockers cause gingival hyperplasia?
The calcium antagonist induces blockage of the aldosterone synthesis in zona glomerulosa of the adrenal cortex since this pathway is calcium-dependent, cyclic nucleotide-independent. This may produce a feedback stimulation of an increase in pituitary secretion of ACTH which affects zona glomerulosa hyperplasia.
Will gingival hyperplasia go away?
In some cases, some other diseases can also cause gingival hyperplasia. Hormonal imbalance during pregnancy is one of these conditions. Diabetes, anemia, and HIV can also cause gingival hyperplasia. Once you get treated for these underlying conditions, gingival hyperplasia also goes away.
How do you treat gingival hyperplasia?
What is the treatment for gingival hyperplasia?
- Removal of bacterial plaque by thorough tooth brushing and flossing.
- Antiseptic mouthwashes such as chlorhexidine.
- Ultrasonic treatments.
- Courses of antibiotics to reduce oral bacterial load (e.g. erythromycin or azithromycin)
Is drug induced gingival hyperplasia reversible?
Drug-induced gingival enlargement has a good prognosis and is generally reversible on stopping or substituting the offending drug.
Which antihypertensive causes gingival hyperplasia?
Amlodipine, a calcium channel blocker, used as antihypertensive drug has been found associated with gingival hyperplasia.
How do you fix gingival hyperplasia?
What medications commonly cause gingival hyperplasia?
Abstract. Drug-induced gingival overgrowth is a side effect associated principally with 3 types of drugs: anticonvulsant (phenytoin), immunosuppressant (cyclosporine A), and various calcium channel blockers (nifedipine, verapamil, diltiazem).
Can blood pressure tablets cause swollen gums?
Gingival enlargement is one of the side effects associated with certain drugs. Amlodipine, a calcium channel blocker, used as antihypertensive drug has been found associated with gingival hyperplasia.
Who should not use calcium channel blockers?
You have kidney or liver disease. You have low blood sugar. This medicine can lower your blood sugar if your daily dose is more than 60 mg. You have Parkinson’s disease.
Can you take nifedipine and amlodipine together?
Interactions between your drugs No interactions were found between amlodipine and nifedipine.