Table of Contents
What causes Subcorneal pustular dermatosis?
The cause of subcorneal pustular dermatosis is unknown. It is not caused by infection and is not contagious or cancerous. Most often it occurs on its own, but has been linked to a variety of other diseases, for example inflammatory bowel disease, arthritis, thyroid disease and blood disorders.
What is Sneddon Wilkinson syndrome?
Subcorneal pustular dermatosis (SPD), also known as Sneddon-Wilkinson disease, is a rare neutrophilic dermatosis in which recurrent crops of sterile pustules appear in the most superficial (subcorneal) layers of the skin (picture 1A-B).
What is epidermolysis bullosa?
Epidermolysis bullosa (EB) is the name for a group of rare inherited skin disorders that cause the skin to become very fragile. Any trauma or friction to the skin can cause painful blisters.
What is pemphigus Foliaceus in humans?
Pemphigus foliaceus is a rare autoimmune blistering disease which is characterised by superficial blisters, erosions and crusts on the skin. This type of pemphigus is less common than pemphigus vulgaris in Australia but in some parts of the world it is “endemic” and very common.
How do you treat Subcorneal pustular dermatosis?
Acitretin. Acitretin (and formally etretinate) has been used to successfully treat subcorneal pustular dermatosis (SPD) and should be considered as an alternative or additional treatment for those who are intolerant of, or unresponsive to, dapsone.
What does Subcorneal mean?
subcorneal (not comparable) Below the cornea.
How does EB affect internal organs?
Junctional Epidermolysis Bullosa In older children and adults, there can be blisters in the lining of the mouth and digestive tract, making it hard to eat and digest food. Children are more likely to have growth and malnutrition issues. Severe cases may be fatal in infancy.
What triggers pemphigus?
Pemphigus vulgaris is not fully understood. Experts believe that it’s triggered when a person who has a genetic tendency to get this condition comes into contact with an environmental trigger, such as a chemical or a drug. In some cases, pemphigus vulgaris will go away once the trigger is removed.
How long can you live with pemphigus?
Untreated, pemphigus vulgaris is often fatal because of the susceptibility to infection and fluid and electrolyte disturbances. Most deaths occur during the first few years of disease, and, if the patient survives 5 years, the prognosis is good.
What does pustular psoriasis look like?
Pustular psoriasis is a skin disease. You’ll see white bumps filled with pus near or inside red skin blotches. These are called pustules. They can hurt and be scaly, flaky, or itchy.
What causes Palmoplantar Pustulosis?
Researchers have found some possible causes including smoking, infections, certain medications and genetics. Smoking: Many patients who have PPP are smokers or have smoked in the past. Smoking may cause sweat glands to become inflamed, especially on the hands and feet, which causes pustules to form.
Is Sneddon-Wilkinson disease an autoimmune disease?
Subcorneal pustular dermatosis (SPD) or Sneddon-Wilkinson disease is a rare, benign, chronic, sterile pustular eruption which is associated with various systemic diseases including immunoglobinopathies, neoplasms, and autoimmune disorders.
What does Sweet disease look like?
The major symptom of Sweet syndrome is the sudden onset of tender or painful bumps (nodules or papules) on the arms, legs, face or neck. They may also occur on the thighs and trunk. Papules are solid, raises lesions; nodules are slightly larger and may extend deeper into the skin.
What is intraepidermal squamous cell carcinoma in situ?
“Intraepidermal” means that the cancerous cells are located in the epidermis from where they originally developed (in situ). Squamous cell carcinoma in situ (SCCIS) is a vitiated, superficial growth of cancerous cells on the skin’s outer layer.
What is intraepidermal skin cancer (SCC)?
It is also known as Bowen disease, intraepidermal carcinoma (IEC) and carcinoma in situ (SCC in situ). Intraepidermal SCC is derived from squamous cells, the flat epidermal cells that make keratin, the horny protein that makes up skin, hair and nails.
What is an IEC (interstitial epidermal endometriosis)?
What is the significance? IEC is a type of squamous cell skin cancer but one that is confined only to the upper layer of skin (epidermis) – and is therefore fairly easy to treat. The abnormal squamous cells of an IEC are located throughout the epidermis.
What are transitional cell carcinomas (TCC) of urinary tract?
Greater than 90% of urinary tract cancers are transitional cell carcinomas (TCC) known today as urothelial carcinomas (UC).[1] Rarer cancers include squamous cell carcinoma, small cell carcinoma, and adenocarcinoma.