Table of Contents
What is AKT full form?
The name Akt stands for Ak strain transforming. The origins of the Akt name date back to 1928, when J. Furth performed experimental studies on mice that developed spontaneous thymic lymphomas.
What is phospho AKT?
Phospho-Akt (Ser473) Antibody detects endogenous levels of Akt1 only when phosphorylated at Ser473. This antibody also recognizes Akt2 and Akt3 when phosphorylated at the corresponding residues.
What is Akt 4 used for?
Akt 4 Kit is a combination of medicines that is used to treat tuberculosis, an infectious disease that mainly affects the lungs but can affect other parts of the body as well. It kills as well as stops the growth of infection causing bacteria and helps in treating the infection.
When should I take Akt 4?
Take A K T 4 Kit Tablet 30minutes before food or 2hours after food. Swallow A K T 4 Kit Tablet as a whole; do not crush or chew the tablet. The dose and duration of A K T 4 Kit Tablet can vary depending upon your condition and severity of the infection.
What is Akt S473?
Phosphorylation of S473 is required for maximal activation of AKT. In the wild-type AKT protein, this phosphorylation leads to further stabilization of the N-lobe of the kinase. The entire regulatory domain wraps around the AKT kinase with the phosphorylated S473 nestled atop the α helix.
Does mTORC2 phosphorylate Akt?
mTORC2 has two key functions, phosphorylation of Akt (Sarbassov et al., 2005) and at the plasma membrane mTORC2 was shown to promote reorganization of cytoskeleton by activating RhoA GTPases and protect cell survival by up regulating anti-apoptotic proteins, the BCL2 (Goncharova et al., 2011).
How is AKT 4 given?
Take A K T 4 Kit Tablet 30minutes before food or 2hours after food. Swallow A K T 4 Kit Tablet as a whole; do not crush or chew the tablet. Take A K T 4 Kit Tablet daily at the same time to ensure better efficacy.
Does Akt activate mTOR?
A key effector of Akt is the mammalian target of rapamycin (mTOR). Akt is known to stimulate mTORC1 activity through phosphorylation of tuberous sclerosis complex 2 (TSC2) and PRAS40, both negative regulators of mTOR activity.
What is PDK protein?
Phosphoinositide-dependent Protein Kinase (PDK) Activity Regulates Phosphatidylinositol 3,4,5-Trisphosphate-dependent and -independent Protein Kinase B Activation and Chemotaxis – PMC.
What is the p13 Akt pathway?
PI3K-Akt Pathway is an intracellular signal transduction pathway that promotes metabolism, proliferation, cell survival, growth and angiogenesis in response to extracellular signals. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates.
Is Akt membrane bound?
Membrane binding may restrict Akt activity to specific subcellular compartments and thereby ensure signaling specificity. Indeed, Akt activation is exclusively associated with cellular membranes.
How do you take an Akt 3 tablet?
Take Akt 3 Kit exactly as directed by your doctor. It is best to take the medicine on an empty stomach one hour before or two hours after meals.
Which Akt isoform should we target for cancer therapy?
In summary, our notion about which Akt isoform to target for cancer therapy is changing. Most studies are consistent with the roles for Akt1 in cell proliferation, cell survival and tumorigenesis and it appears to play a predominant role in hormone receptor-positive breast cancers.
Is there a relationship between AKT3 and FASN in breast cancer?
Akt isoform specificity has yet to be extensively studied in breast cancer in relation to FASN, although prostate cancer studies have revealed a relationship between Akt3 and FASN involving the two as downstream effectors of peroxisome proliferator-activated receptor gamma (PPARG) activation [154].
How does Akt activation affect metabolic regulation in cancer cells?
Akt isoforms have been studied for their ability to affect metabolic regulation in cancer cells. Oncogenic Akt activation plays a major role in meeting the metabolic needs of the tumorigenic process.
Are breast tumor cells with PI3K mutations addicted to Akt signaling?
She Q.B., Chandarlapaty S., Ye Q., Lobo J., Haskell K.M., Leander K.R., DeFeo-Jones D., Huber H.E., Rosen N. Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling. PLoS ONE. 2008;3:e3065. doi: 10.1371/journal.pone.0003065.