What is OECD 407?
1 OECD Guidelines for the Testing of Chemicals are periodically reviewed in the light of scientific progress. The original Test Guideline 407 was adopted in 1981. In 1995 a revised version was adopted, to obtain additional information from the animal used in the study, in particular on neurotoxicity and immunotoxicity.
Which rodent is used for oral toxicity study?
For a classical LD50 study, laboratory mice and rats are the species typically selected. Often both sexes must be used for regulatory purposes. When oral administration is combined with parenteral, information on the bioavailability of the tested compound is obtained.
What is Acute oral toxicity?
Acute oral toxicity refers to those adverse effects occurring following oral administration of a single dose of a substance, or multiple doses given within 24 hours. Delayed death means that an animal does not die or appear moribund within 48 hours but dies later during the 14-day observation period.
What OECD 408?
The OECD 408: Repeated Dose 90-Day Oral Toxicity Study is used to determine the toxicity of an orally ingested chemical over a prolonged time period. It is often carried out as a follow-on study to acute or repeated dose 28-day oral toxicity studies to determine the sub-chronic oral toxicity of the test substance.
What is meant by OECD test guidelines?
The OECD Guidelines for the testing of chemicals are a collection of the most relevant internationally agreed testing methods used by governments, industry and independent laboratories to assess the safety of chemicals.
What is OECD Guidelines full form?
OECD Guidelines for the Testing of Chemicals (OECD TG) are a set of internationally accepted specifications for the testing of chemicals decided on by the Organisation for Economic Co-operation and Development (OECD). They were first published in 1981.
What is LC50?
This concentration is usually quoted as parts per million (ppm) or milligrams per cubic metre (mg/m3). In these experiments, the concentration that kills 50% of the animals is called an LC50 (Lethal Concentration 50) rather than an LD50.
What OECD 401?
In 1987, OECD 401 was revised, primarily for animal welfare reasons. The test could now be conducted using animals of only one sex, with confirmation that there were no sex differences in the acute toxicity of a test material by testing at just one dose level in the second sex.
What is OECD full form?
Glossary:Organisation for Economic Co-operation and Development (OECD) The Organisation for Economic Co-operation and Development, abbreviated as OECD and based in Paris (FR), is an international organisation of 38 countries committed to democracy and the market economy.