Table of Contents
What is amitriptyline made of?
Each tablet contains the following inactive ingredients: colloidal silicon dioxide, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate, sodium starch glycolate and titanium dioxide. The 10 mg tablets also contain FD&C blue #1 lake.
What class of drug is amitriptyline?
Amitriptyline is in a class of medications called tricyclic antidepressants. It works by increasing the amounts of certain natural substances in the brain that are needed to maintain mental balance.
Is amitriptyline an acid or base?
Amitriptyline is a highly lipophilic molecule having an octanol-water partition coefficient (pH 7.4) of 3.0, while the log P of the free base was reported as 4.92. Solubility of the free base amitriptyline in water is 14 mg/L.
What is the chemical name of Elavil?
Amitriptyline hydrochloride, also known as Elavil, is a tricyclic antidepressant (TCA) with analgesic properties, widely used to treat depression and neuropathic pain 5.
Does amitriptyline increase dopamine?
5. Increases of regional brain dopamine by amitriptyline and serotonin by nortriptyline concurrent with reuptake blockade of the respective serotonin and dopamine may contribute to their differential extrapyramidal and sedating side effects.
Is amitriptyline a serotonin?
Amitriptyline is an antidepressant medicine. It works by increasing levels of a chemical called serotonin in your brain. This can improve your mood. You may start to feel better after 1 to 2 weeks but it can take 4 to 6 weeks for amitriptyline to work fully.
Does amitriptyline increase serotonin?
Amitriptyline is from a group of medicines called tricyclic antidepressants. They are thought to work by increasing levels of a chemical called serotonin in your brain. This can improve your mood.
Does amitriptyline block dopamine?
No protective effect of any of the drugs or doses tested was found. This is in contrast to our previous work showing that amitriptyline can protect dopamine cells, albeit in a less severe degeneration model.
Is amitriptyline abused?
Elavil Addiction And Abuse. Elavil is a commonly prescribed Antidepressant that is also used to treat pain stemming from conditions such as arthritis and fibromyalgia. Although generally considered to be nonaddictive, the drug is still regularly abused due to its euphoric and sedative effects.
Is amitriptyline a carcinogen?
The human studies showed a transiently statistically significant positive association between amitriptyline and liver cancer and a negative association with pancreatic cancer; and that the antidepressants amitriptyline, nortriptyline, desipramine, and phenelzine may increase risk of breast cancer.
What is the weakest antidepressant?
Those that made the least-effective list of antidepressant drugs sold in the United States included: Luvox (fluvoxamine) Oleptro (trazodone) Prozac (fluoxetine)
What is the strongest anti depressant?
The most effective antidepressant compared to placebo was the tricyclic antidepressant amitriptyline, which increased the chances of treatment response more than two-fold (odds ratio [OR] 2.13, 95% credible interval [CrI] 1.89 to 2.41).
Is gabapentin better than amitriptyline?
Gabapentin produced greater improvements than amitriptyline in pain and paresthesia associated with diabetic neuropathy. Additionally, gabapentin was better tolerated than amitriptyline. Further controlled trials are needed to confirm these preliminary results.