Table of Contents
What is mesna used for?
Mesna is used to reduce the risk of hemorrhagic cystitis (a condition that causes inflammation of the bladder and can result in serious bleeding) in people who receive ifosfamide (a medication used for the treatment of cancer). Mesna is in a class of medications called cytoprotectants.
Is Mesna a chemo?
Mesna is a drug given with some types of chemotherapy to help protect the bladder from irritation.
How does Mesna prevent hemorrhagic cystitis?
Administration of Mesna (2-mercaptoethane sulfonate sodium) before initiation of cyclophosphamide can prevent hemorrhagic cystitis by binding to and neutralizing acrolein.
How is mesna administered?
Where ifosfamide or cyclophosphamide is used as an iv bolus: Mesna is given by intravenous injection over 15-30 minutes at 20% of the simultaneously administered oxazaphosphorine on a weight for weight basis (w/w). The same dose of mesna is repeated after 4 and 8 hours.
Can mesna be given orally?
Oral mesna is taken by mouth, usually 2 and 6 hours after you receive ifosfamide. Mesna is given either in a series of 3 injections spaced 4 hours apart, or as a single injection followed by 2 oral doses spaced 2 and 6 hours later. Follow your doctor’s dosing instructions very carefully.
Is mesna effective?
A total of 68 cycles of cyclophosphamide were given with mesna, with a median of three cycles per patient. A recurrence of cystitis was prevented in all but one patient. Thus, mesna is effective in preventing recurrent cystitis in patients receiving further cyclophosphamide.
What is mesna injection?
What is mesna effect?
Mesna helps to protect the lining of the bladder against damage from ifosfamide. The body breaks down ifosfamide to form a product that can harm the bladder, and mesna works by making this product less harmful. However, mesna does not change ifosfamide’s anti-cancer effects.
How do you give an IV mesna?
When is mesna required with cyclophosphamide?
Mesna should always be given with ifosfamide and high dose cyclophosphamide if hyperhydration is not being used.
How fast can you give mesna?
Where ifosfamide or cyclophosphamide is used as an iv bolus: Mesna is given by intravenous injection over 15-30 minutes at 20% of the simultaneously administered oxazaphosphorine on a weight for weight basis (w/w).
How do you give a mesna injection?
When do you give mesna with Cytoxan?
How is mesna supplied?
Intravenous Administration Mesna injection should be diluted to obtain a final concentration of 20 mg/ml. Mesna may be given as a rapid IV infusion/bolus or as a continuous infusion. Mesna is compatible with cyclophosphamide and ifosfamide in the same infusion fluid and may be admixed for continuous infusion.