Table of Contents
What is the function of LET-7?
The let-7 microRNAs regulate the cell proliferation, cell cycle, apoptosis, metabolism, and stemness. In CRC, expressions of let-7 microRNAs have been reported to be reduced, and so let-7 microRNAs are considered to be a tumor suppressor.
What is the Let-7 gene?
The lethal-7 (let-7) gene was first discovered in the nematode as a key developmental regulator and became one of the first two known microRNAs (the other one is lin-4). Soon, let-7 was found in fruit fly, and identified as the first known human miRNA by a BLAST (basic local alignment search tool) research.
What is let-7 cancer?
In breast cancer, let-7 targets estrogen receptors, which activate WNT signaling and promote stemness and cancer aggressiveness [40]. Let-7 down-regulates WNT signalling activity by targeting estrogen receptors in breast cancer and TCF-4 (a transcription factor downstream of WNT) in hepatocellular carcinoma.
What is the role of the LET-7 family of miRNA in human embryonic stem cell pluripotency?
In summary, the three let-7 targets, HMGA2, IMP-1 and Lin28 can be connected to stem cell function, thus making let-7 and its oncofetal targets fundamental regulators of stem cells, and therefore, highly relevant to cancer development and therapy.
How does Lin28 let 7 control development and disease?
During embryonic development Lin28 levels decline allowing an accumulation of let-7 miRNAs. let-7 induction inhibits the self-renewal of undifferentiated cells and promotes differentiation. Introduction of synthetic let-7 is sufficient to rescue the compromised differentiation phenotype of miRNA-deficient ESCs[20].
What is Oligopotent?
(biology) Describing a stem cell that is able to form two or more mature cell types within a tissue.
What is miRNA and RNAi?
In jargon, RNA interference (RNAi) is a post-transcriptional regulatory mechanism that uses small RNAs (including microRNAs (miRNAs) and small interfering RNAs (siRNAs)) as guides to direct a protein called Argonaute (Ago) to bind to and repress target messenger RNAs (mRNAs) containing sequence complementarity to that …
What is the let-7 family?
The let-7 family. The lethal-7 (let-7) gene was first discovered in the nematode as a key developmental regulator and became one of the first two known microRNAs (the other one is lin-4). Soon, let-7 was found in fruit fly, and identified as the first known human miRNA by a BLAST (basic local alignment search tool) research.
What is let-7 miRNA?
Let-7 miRNA was first discovered in Caenorhabditis elegans and it is highly conserved in human tissues. The human let- 7 family of miRNA contains 12 members of miRNA.
What is lethal-7 (let-7)?
The lethal-7 (let-7) gene was first discovered in the nematode as a key developmental regulator and became one of the first two known microRNAs (the other one is lin-4 ). Soon, let-7 was found in fruit fly, and identified as the first known human miRNA by a BLAST (basic local alignment search tool) research.
What do we know about let-7 Drosophila let-7?
Drosophila let-7 is first detected by northern blots at the end of the 3rd larval instar 55, 56, and a role for let-7 in the transition from the 3rd instar to the pupal stage has just now become apparent.