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What is Doribax used for?
Doribax is a prescription medicine used to treat the symptoms of Complicated Intra-abdominal Infection and complicate Urinary Tract Infection (UTI). Doribax may be used alone or with other medications. Doribax belongs to a class of drugs called Carbapenems.
What class is doripenem in?
Doripenem injection is in a class of medications called carbapenem antibiotics. It works by killing bacteria.
Is doripenem safe in renal failure?
dose adjustment is necessary. In patients with moderate renal impairment (CrCl ≥ 30 to ≤ 50 ml/min), the dose of doripenem should be 250 mg every 8 hours (see section 6.6). In patients with severe renal impairment (CrCl < 30 ml/min), the dose of doripenem should be 250 mg every 12 hours (see section 6.6).
When was doripenem discovered?
It was launched by Shionogi Co. of Japan under the brand name in 2005 and is being marketed outside Japan by Johnson & Johnson. Doripenem was approved by the United States Food and Drug Administration on October 12, 2007, to be sold under the tradename Doribax.
Can doripenem be given orally?
Doripenem is usually given for 5 days to 2 weeks, depending on the condition being treated. You may be switched to an oral (pill form) antibiotic after the first few days of receiving doripenem by injection. Doripenem is a powder that must be mixed with a liquid (diluent).
Does doripenem cover MRSA?
This class is bactericidal in nature, but it does not cover species of Enterococcus faecium, methicillin-resistant Staphylococcus aureus (MRSA), or Stenotrophomonas maltophilia. Collectively, the carbapenems have been used to treat a variety of infections.
Why is doripenem not used?
In March 2014, the FDA issued a warning statement against Doribax (doripenem) for ventilator associated pneumonia, saying: Doribax carries an increased risk of death and lower clinical cure rates compared to use of imipenem and cilastatin Doribax is not approved to treat any type of pneumonia.
Is doripenem bacteriostatic or bactericidal?
Doripenem displays bactericidal action against susceptible species, stability to human renal DHP and beta-lactamases (including extended spectrum beta-lactamases [ESBLs], pharmacokinetic and pharmacodynamic profiles similar to meropenem (including minimal risk of seizure as an adverse reaction), post-antibiotic effects …
Is there a generic version of Doribax?
The Doribax brand name has been discontinued in the U.S. If generic versions of this product have been approved by the FDA, there may be generic equivalents available. What is Doribax? Doribax (doripenem) is an antibiotic that fights bacteria. Doribax is used to treat severe infections of the stomach, bladder, or kidneys.
Should Doribax ® be prescribed to patients with bacterial infections?
Prescribing Doribax ® in the absence of a proven or strongly suspected bacterial infection is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria. When Doribax ® has been used investigationally via inhalation, pneumonitis has occurred. Doribax ® should not be administered by this route.
What are the side effects of Doribax?
Doribax side effects. Get emergency medical help if you have any signs of an allergic reaction to Doribax: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: severe stomach pain;
Are there any overages used in the manufacture of doripenem powder for infusion?
Overages: There are no overages used in the manufacture of doripenem powder for infusion. Sterility Assurance: The drug product is manufactured by aseptic filling of sterile doripenem monohydrate powder. The manufacturing procedures for the drug product ensure microbiological control at each step of the drug product manufacturing process.