What is von Willebrand disease profile?
VON WILLEBRAND DISEASE PROFILE. Page 1. BACKGROUND: von Willebrand disease (VWD) is a common bleeding disorder characterized by either quantitative or qualitative defects of von Willebrand factor (VWF). Screening tests for VWD include Factor VIII activity, VWF antigen, and VWF GPIbM activity.
Is PT and PTT normal in von Willebrand disease?
The prothrombin time (PT) is normal in VWD. Although some laboratories may also include a skin bleeding time and platelet function analysis (PFA closure time) in their evaluation of an individual with suspected VWD, these tests lack sensitivity in persons with mild bleeding.
What are the levels of von Willebrand disease?
There are three major subtypes of von Willebrand disease, classified as partial quantitative deficiency (low levels) of von Willebrand factor (type 1), qualitative deficiency (type 2), or virtually complete deficiency (type 3).
Does von Willebrand disease affect INR?
Key Points. Patients with von Willebrand disease have easy bruising and purpura, usually mucosal, and rarely joint bleeding. Screening tests reveal a normal platelet count, normal INR, and sometimes a slightly prolonged PTT.
What is von Willebrand panel?
What is this test? This panel of tests is used to diagnose von Willebrand disease. This is a bleeding disorder that causes excessive bleeding from minor injuries or normal physical processes such as menstruation. It’s the most common inherited bleeding disorder, but few people with the disease have symptoms.
What is the normal range for factor VIII?
Test results are usually reported as a percentage of a “normal” result of 100%. Normal ranges for factor VIII levels are 50% to 150%. If your factor VIII activity level is less than 50%, you may have hemophilia A, but how severe your risk of bleeding is depends on what percentage you have.
What is a high level of Factor 8?
Persistent elevation of factor VIII above 150% is associated with an increased risk for venous thrombosis of more than fivefold. Elevated factor VIII is also associated with an increased risk for recurrence of venous thromboembolism. Risk is graded such that the higher the factor VIII activity, the higher the risk.
What is a low factor 8?
Hemophilia A, also called factor VIII (8) deficiency or classic hemophilia, is a genetic disorder caused by missing or defective factor VIII (FVIII), a clotting protein. Although it is passed down from parents to children, about 1/3 of cases found have no previous family history.
Can von Willebrand disease cause joint pain?
For example, patients with Type 3 von Willebrand disease may experience bleeding into the joints or joint spaces (also known as a hemarthrosis) because they also have a low factor VIII level. Symptoms of joint bleeding include joint pain and swelling.
What is the most common type of von Willebrand disease (vWD)?
It is important for a person with VWD to know which type he or she has. Type 1 VWD is the most common type. About 85% of the people with VWD have this type. In Type 1 VWD, there is not enough von Willebrand factor (VWF) in the bloodstream. The VWF works correctly but the body needs more of it to adequately control bleeding.
What blood tests can diagnose von Willebrand disease?
The blood tests that a doctor can order to diagnose VWD (or another platelet disorder) include: Factor VIII clotting activity―To measure the amount of factor VIII in the blood Von Willebrand factor antigen―To measure the amount of VWF in the blood Ristocetin cofactor or other VWF activity―To measure how well the VWF works
How common is von Willebrand factor (VWF) deficiency?
About 85% of the people with VWD have this type. In Type 1 VWD, there is not enough von Willebrand factor (VWF) in the bloodstream. The VWF works correctly but the body needs more of it to adequately control bleeding. Since VWF protects factor VIII from being destroyed, a low level of VWF may also mean a lower level of factor VIII.
What is the difference between hemophilia and von Willebrand?
Factor VIII is the protein that is inactive or missing in hemophilia, another clotting disorder. Von Willebrand disease, like hemophilia, is an inherited bleeding disorder, but VWD is more common and usually milder. In fact, VWD is the most common of all the inherited bleeding disorders.