Table of Contents
What are pH sensitive hydrogels?
A pH-sensitive hydrogel is a gel structure that is sensitive to changes in pH. Most commonly, the hydrogel will swell or contract in response to a change in the local chemical environment.
How do pH-responsive hydrogels work?
pH-sensitive hydrogels consist of a backbone polymer either containing weak acidic groups or basic groups which become more ionized in higher or lower pH environments, respectively. Mechanical stability is attributed to the backbone polymer while the ionizable component provides the pH sensitivity.
What is pH-responsive drug delivery system?
pH-Responsive drug-delivery systems have attracted more and more interest as “smart” drug-delivery systems for overcoming the shortcomings of conventional drug formulations because they are able to deliver drugs in a controlled manner at a specific site and time, which results in high therapeutic efficacy.
What is the pH of hydrogel?
pH responsive hydrogels are developed, which shows highest swelling capacity around physiological pH~ 7.4, compared to both acidic and basic medium. Synthesis of hydrogels using green azetidinium-amine reactions in water. Selective and controlled drug delivery at pH 7.4, compared to both acidic and basic medium.
How does different pH in the body affect drug delivery?
Having pH-sensitivity, cationic polymers can mask the taste of drugs and release drugs in the stomach by responding to gastric low pH. Anionic polymers responsive to intestinal high pH are used for preventing gastric degradation of drug, colon drug delivery and achieving high bioavailability of weak basic drugs.
How do you measure pH of hydrogel?
put a slightly wet pH-paper on the surface of the hydrogel. Cheap, easy, not so precise. 2. you can buy flat pH-electrodes, which are used for the determination of surface pH of solids.
What are various applications of pH sensitive smart polymers?
Key uses of pH sensitive polymers are controlled drug delivery systems, biomimetics, micromechanical systems, separation processes, and surface functionalization.
How do you find the pH of a hydrogel?
For accurate measurement you can use ph Meter. You can use glass electrode – pH meter. There is no special method available for measuring the pH of gel, but you can use glass electrode based pH-meter system for this purpose. But keep in mind that pH must be recorded without any dilution.
Why is pH important in drugs?
It may seem trivial, but the conductivity and pH of certain materials and ingredients determines how a drug formulation, or specific ingredients within the formulation, functions within a system. That makes it important to understand the acidity or alkalinity of that material and the system itself.
What is the meaning of pH sensitive?
pH sensitive or pH responsive polymers are materials which will respond to the changes in the pH of the surrounding medium by varying their dimensions. Materials may swell, collapse, or change depending on the pH of their environment.
What are the applications of pH-sensitive hydrogels?
Applications of pH-sensitive hydrogels 3.3.1. Controlled drug delivery pH-sensitive hydrogels have been most frequently used to develop controlled release formulations for oral administration.
What are the environment-sensitive hydrogels for drug delivery?
Environment-sensitive hydrogels for drug delivery 1 Introduction. Controlled drug delivery systems, which are intended to deliver drugs… 2 Temperature-sensitive hydrogels. Temperature-sensitive hydrogels are probably… 3 pH-sensitive hydrogels. All the pH-sensitive polymers contain pendant acidic (e.g. 4 Glucose-sensitive hydrogels. One…
Can hydrogels be used as biosensors and drug delivery systems?
For this reason, either pH-sensitive and/or temperature-sensitive hydrogels can be used for site-specific controlled drug delivery. Hydrogels that are responsive to specific molecules, such as glucose or antigens, can be used as biosensors as well as drug delivery systems.
Are hydrogels suitable for drug delivery of peptide drugs?
For the application of drug delivery, the drug is incorporated into the polymer backbone.26,48-52pH-sensitive hydrogels have been investigated frequently for the use in drug delivery of peptide drugs.