Table of Contents
What is temporal lobe epilepsy with hippocampal sclerosis?
Mesial temporal lobe epilepsy is often associated with changes or abnormal findings on MRI (magnetic resonance imaging). One of the most common findings is scarring in the temporal lobe. This is called hippocampal sclerosis (sclerosis means hardening or scarring).
Is hippocampal sclerosis epilepsy?
Hippocampal sclerosis is the commonest cause of drug-resistant epilepsy in adults, and is associated with alterations to structures and networks beyond the hippocampus.In addition to being a cause of epilepsy, the hippocampus is vulnerable to damage from seizure activity.
What is the most common cause of temporal lobe epilepsy?
Often, the cause of temporal lobe seizures remains unknown. However, they can be a result of a number of factors, including: Traumatic brain injury. Infections, such as encephalitis or meningitis, or a history of such infections.
How do you get hippocampal sclerosis?
Brain damage from traumatic injury, infection, a brain tumor, stroke, or uncontrolled seizures is thought to cause the scar tissue to form, particularly in the hippocampus.
How is hippocampal sclerosis treated?
Conclusions: Our findings demonstrated that anteromedial temporal lobectomy is a safe and effective treatment method in well-chosen patients with hippocampal sclerosis. This surgical procedure can be performed with a low rate of morbidity even in relatively new epilepsy surgery center.
How common is hippocampal sclerosis?
Hippocampal sclerosis is a relatively common neuropathological finding (∼10% of individuals over the age of 85 years) characterized by cell loss and gliosis in the hippocampus that is not explained by Alzheimer’s disease.
Is hippocampal sclerosis common in mesial temporal epilepsy?
Abstract Hippocampal sclerosis (HS) is a common pathology encountered in mesial temporal lobe epilepsy (MTLE) as well as other epilepsy syndromes and in both surgical and post-mortempractice.
What is the prevalence of neocortical temporal lobe sclerosis (TLS)?
Widespread changes involving neocortical and mesial temporal lobe structures can be present in patients with temporal lobe epilepsy and hippocampal sclerosis. The incidence, pathology, and clinical significance of neocortical temporal lobe sclerosis (TLS) are not well characterized.
What are diffuse and disseminated lesions in hippocampal sclerosis?
In the earliest descriptions of hippocampal sclerosis (HS) in temporal lobe resection specimens, it was recognized that “diffuse and disseminated lesions” may be present in association with this pathology involving the uncus, amygdala, and lateral temporal neocortex ( 1 ).
Does temporal lobe tachycardia (TLS) affect seizure outcome?
No obvious effect of TLS on seizure outcome was noted after temporal lobe resection; 73% became seizure-free at 2-year follow-up. In conclusion, approximately 11% of surgically treated hippocampal sclerosis is accompanied by TLS.