Table of Contents
What is chemical induced vitiligo?
Chemical-associated vitiligo, an acquired disorder that presents with hypo- or depigmented patches, is thought to be induced by repeated exposure to specific chemicals.
How is chemical induced vitiligo treated?
The chemical is called monobenzyl ether of hydroquinone, or monobenzone. In fact, it worked so well that we use it now to remove the remaining pigment from the skin of those with widespread vitiligo, in order to make it even. It is prescribed by dermatologists as Benoquin cream.
What is chemical depigmentation?
Chemical leukoderma (also known as contact leukoderma or occupational vitiligo) is an acquired depigmenting dermatosis caused by repeated or sometimes a single exposure to specific chemicals.
What are the three types of vitiligo?
What are the types of vitiligo?
- Generalized, which is the most common type, when macules appear in various places on the body.
- Segmental, which is restricted to one side of the body or one area, such as the hands or face.
- Mucosal, which affects mucous membranes of the mouth and/or the genitals.
Does chemical induced vitiligo spread?
Depigmentation in chemical vitiligo spreads to distant sites, in the same way as generalized idiopathic vitiligo. The study showed that chemical triggering factors played a very significant role in the induction and progression of vitiligo.
Does drug induced vitiligo go away?
Drug-induced vitiligo usually resolves when the offending drug is discontinued, but the time it takes to happen can vary greatly. Vitiligo is difficult to treat.
Will drug induced vitiligo go away?
What can trigger vitiligo?
It’s possible that vitiligo may be triggered by particular events, such as:
- stressful events, such as childbirth.
- skin damage, such as severe sunburn or cuts (this is known as the Koebner response)
- exposure to certain chemicals – for example, at work.
How do you trigger vitiligo?
It’s possible that vitiligo may be triggered by particular events, such as:
- stressful events, such as childbirth.
- skin damage, such as severe sunburn or cuts (this is known as the Koebner response)
- exposure to certain chemicals – for example, at work.
Can drinking alcohol cause vitiligo?
Everyone’s body is different and may react differently to certain foods. Here are some of the top problem foods that some people with vitiligo cite: alcohol.
What triggers vitiligo to spread?
The most common cause of Vitiligo spread is considered excessive consumption of Vitamin C through food or juice. Vitamin C accelerates the spread of discolored/ white patches. Sour food like Amla, curd, yeasted or fermented food has a high proportion of Vitamin C.
What autoimmune causes vitiligo?
In particular, vitiligo is present within the autoimmune polyendocrine syndromes (51), and it is more frequently encountered in family members of patients affected by autoimmune diseases, such as inflammatory bowel disease, psoriasis, rheumatoid arthritis, type 1 diabetes, systemic lupus erythematosus, pernicious …
Is vitiligo triggered by stress?
Hormonal response to psychological stress such as cortisol has a role in the development of vitiligo. Physical or environmental stress is involved in the onset and disease progression. Psychological stresses can also contribute to the onset and progression of vitiligo.
What drugs cause vitiligo?
What causes drug-induced vitiligo?
- Topical imiquimod.
- Interleukin (IL)-2, IL-4, and interferon.
- Tumour necrosis factor inhibitors: infliximab, adalimumab, and etanercept.
- The programmed death receptor inhibitors, pembrolizumab and nivolumab, used in metastatic melanoma (15% of treated patients develop vitiligo)
What is chemical-induced vitiligo and what causes it?
The term ‘chemical vitiligo’ was first coined by us to indicate the possible relationship between chemical leucoderma and vitiligo, which has been supported recently by other authors to designate the term ‘chemical-induced vitiligo’. The largest case series showed that household chemical exposure was the major etiological factor.
How do phenols cause vitiligo?
Most chemicals that induce vitiligo are phenols and act as tyrosine analogs to disrupt melanocyte function, resulting in autoimmunity The use of phenols is widespread as ingredients in household commercial products
What is the role of hydrogen peroxide in the pathogenesis of vitiligo?
To date there is ample evidence that patients with vitiligo accumulate millimolar concentrations of hydrogen peroxide (H2O2) in their epidermis as well as in their blood lymphocytes/monocytes. Several enzymes are affected by this H2O2 including catalase, glutathione peroxidase, and 4a-carbinolamine dehydratase.
Can benzoyl peroxide cause vitiligo?
The main mechanism of action of benzoyl peroxide depends on the release of oxygen free-radicals, which are capable of oxidizing bacterial proteins. However, this same mechanism can also damage melanocytes in people with skin depigmentation. Link to vitiligo: there have been cases where usage of retinoic acid has triggered the onset of vitiligo.