Is Domitor a medetomidine?
Description. Domitor (medetomidine hydrochloride) is a synthetic α2-adrenoreceptor agonist with sedative and analgesic properties.
What is the difference between dexmedetomidine and medetomidine?
Medetomidine is faster acting and more effective than dexmedetomidine following IM administration in dogs. Medetomidine may induce less vasoconstriction at injection site, faster uptake and more rapid onset of action.
How long does medetomidine last for?
The analgesia associated with medetomidine only lasts 15 to 30 minutes but sedation can last 1 to 2 hours. Complete recovery can take 2 to 4 hours.
What kind of drug is medetomidine?
surgical anesthetic
Medetomidine is a synthetic compound used as a surgical anesthetic and analgesic. It is normally found as its hydrochloride salt, medetomidine hydrochloride. Medetomidine is an intravenously available alpha-2 adrenergic agonist. The drug has been developed by Orion Pharma.
What is medetomidine used for?
The pharmacological restraint and pain relief provided by medetomidine facilitates handling dogs and aids in the conduct of diagnostic or therapeutic procedures. It also facilitates minor surgical procedures (with or without local anesthesia) and dental care where intubation is not required.
Is dexmedetomidine safer than medetomidine?
Conclusions and clinical relevance: Dexmedetomidine is at least as safe and effective as medetomidine for use as a premedicant in dogs undergoing propofol-isoflurane anesthesia.
Does medetomidine cause hypotension?
While hypotension may occur, sedative doses of medetomidine typically raise the blood pressure, due to the effect on peripheral α2-adrenoreceptors.
How is medetomidine given?
Medetomidine has some advantages. It can be given by subcutaneous rather than intramuscular injection. It provides good laryngeal relaxation for endotracheal intubation. It is not a respiratory depressant and recovery is usually complete within 3 h.
Can you give medetomidine IV?
Medetomidine (Domitor) and butorphanol can be administered together in the same syringe, by IM or IV injection. Dose rate: 10-25 mcg/kg medetomidine (0.01 – 0.025 ml/kg Domitor), depending on the degree of sedation required, plus 0.1mg/kg butorphanol (0.01ml/kg of 10mg/ml solution).
How many mg of medetomidine in Domitor?
Each mL of Domitor contains 1.0 mg medetomidine hydrochloride, 1.0 mg methylparaben (NF), 0.2 mg propylparaben (NF), 9.0 mg sodium chloride (USP), and water for injection (USP), q.s. Medetomidine is a potent non-narcotic α2-adrenoreceptor agonist which produces sedation and analgesia. These effects are dose dependent in depth and duration.
What are the effects of medetomidine?
Medetomidine is a potent non-narcotic α2-adrenoreceptor agonist which produces sedation and analgesia. These effects are dose dependent in depth and duration. Profound sedation and recumbency, with reduced sensitivity to environmental stimuli (sounds, etc.), are seen with medetomidine.
What class of drug is medetomidine?
Medetomidine belongs to a class of drugs known as alpha 2 adrenergic agonists and is similar to clonidine and xylazine. It is a sedative that provides pain relief as well as muscle relaxation. After intramuscular (IM) injection, the effects of medetomidine are seen within 10 to 15 minutes.
How much medetomidine do you give for sedation?
Dose rate: 10-25 mcg/kg medetomidine (0.01 – 0.025 ml/kg Domitor), depending on the degree of sedation required, plus 0.1mg/kg butorphanol (0.01ml/kg of 10mg/ml solution). Allow 20 minutes for sedation to develop before commencing the procedure.