What is the structure of primaquine?
C15H21N3OPrimaquine / Formula
Why is primaquine given with chloroquine?
vivax malaria are treated with chloroquine for three days to eliminate the parasites in the blood that cause the symptoms of malaria, followed by 15 mg/day of primaquine for 14 days to treat the liver stage of the infection to prevent the disease recurring.
What is the mechanism of action of primaquine?
Primaquine acts by interfering with a part of the parasite (mitochondria) that is responsible for supplying it with energy. Without energy the parasite dies. This stops the infection from continuing and allows the person to recover.
What is primaquine explain it?
Primaquine is in a class of medications called antimalarials. It works by killing the organisms that cause malaria.
Is malaria a DNA or RNA virus?
Anopheles vectors of human malaria in Africa and Asia are ubiquitously colonized by RNA viruses, some of which are monophyletic but clearly diverged from other arthropod viruses.
What is the difference between chloroquine and primaquine?
Chloroquine is a highly effective schizontocide, while primaquine has weaker asexual-stage activity (3) but is the only generally available drug with hypnozoitocidal properties, i.e., it kills dormant liver stage parasites and prevents relapse (radical cure) (1).
What is the function of primaquine?
Primaquine is used alone or with another medication to treat malaria (a serious infection that is spread by mosquitoes in certain parts of the world and can cause death) and to prevent the disease from coming back in people that are infected with malaria. Primaquine is in a class of medications called antimalarials.
What are stages of malaria?
Like all mosquitoes, anopheles mosquitoes go through four stages in their life cycle: egg, larva, pupa, and adult. The first three stages are aquatic and last 7-14 days, depending on the species and the ambient temperature. The biting female Anopheles mosquito may carry malaria.
How does primaquine cause hemolytic anemia?
Unfortunately, primaquine causes dangerous side effects in certain individuals who are deficient in an enzyme called G6PD, which helps defend red blood cells against stresses. Primaquine damages these cells so that they burst, leading to anaemia.
How does primaquine work in the body?
Primaquine belongs to a group of medicines, called antiprotozoals. It works by treating malaria, a red blood cell infection transmitted by the bite of a mosquito. It also prevents the development of the blood forms of the parasite, which are responsible for the relapse.
What is yellow fever scientific name?
Yellow fever (YF) is an African mosquito-borne infection of primates. It is caused by a virus of the Flavivirus genus of the Flaviviridae family.
What class of drug is primaquine?