Does vinorelbine cause hair loss?
When used on its own, vinorelbine may cause some mild, temporary hair thinning. Very rarely, it can cause complete hair loss.
Is vinorelbine a chemo drug?
Vinorelbine is a type of chemotherapy. You might have it as a treatment for: advanced breast cancer. Non small cell lung cancer.
What is vinorelbine made from?
Vinorelbine belongs to a class of chemotherapy drugs called plant alkaloids. Plant alkaloids are made from plants. The vinca alkaloids are made from the periwinkle plant (catharanthus rosea). The taxanes are made from the bark of the Pacific Yew tree (taxus).
What is the antidote for vinorelbine?
There is no known specific antidote. – broad spectrum antibiotic therapy may be necessary in case of complications due to infections. There is no known antidote for overusage of vinorelbine. Vinorelbine is a cytostatic drug of the Vinca alkaloid family.
Does vinorelbine cause nausea?
Nausea, vomiting, fatigue, constipation, diarrhea, dizziness, muscle aches, joint pain, or irritation at the injection site may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.
Does vinorelbine cause neuropathy?
Mild to moderate peripheral neuropathy occurs in 7% to 31% of patients treated with vinorelbine, whereas severe toxicity has been reported in only a few cases and is particularly associated with concomitant or previous treatment with paclitaxel.
Does vinorelbine cross the blood brain barrier?
Most commonly used cytotoxic chemotherapy agents (namely taxanes and vinorelbine, but also pemetrexed and gemcitabine) do not readily cross the intact blood-brain barrier nor are they actively pumped out; responses occasionally reported may not be meaningful and will not treat micrometastatic disease.
How do you take Navelbine?
It is preferable to take Navelbine with a light meal. Navelbine should not be taken with a hot drink as it will dissolve the capsule too quickly. Men being treated with Navelbine are advised not to father a child during and up to 3 months after the last capsule.
How do you stop vinorelbine induced irritation?
Conclusion: Rapid infusion and dilution are effective methods of reducing phlebitis caused by the infusion of VNR, but the efficacy of flushing with normal saline or infusion of fat emulsion was not confirmed.
What type of chemo crosses the blood-brain barrier?
Types of chemotherapy drugs Nitrosoureas, a type of alkylating agent, can cross the blood-brain barrier and interfere with enzymes that help repair DNA.
Is vinorelbine a Vesicant?
Vinorelbine is a vesicant and can cause significant tissue damage; avoid extravasation. Refer to UpToDate topic on “Extravasation injury from chemotherapy and other non-antineoplastic vesicants”.
Does vinorelbine cross the blood-brain barrier?