What is the infusion rate for vancomycin?
Vancomycin should be infused slowly in a dilute solution (2.5 to 5.0 mg/ml) at a rate no greater than 10 mg/min and over a period not less than 60 minutes to avoid rapid infusion-related reactions. Stopping the infusion usually results in a prompt cessation of these reactions.
How do you administer vancomycin IV?
Vancomycin injection comes as a powder to be added to fluid and injected intravenously (into a vein). It is usually infused (injected slowly) over a period of at least 60 minutes once every 6 or 12 hours, but may be given every 8 hours in newborn babies.
Can vancomycin be mixed with dextrose?
Vancomycin hydrochloride is stable in admixtures with 5% dextrose injection and 0.9% sodium chloride injection for 17 days at 24 degrees C and for 63 days at 5 degrees C and -10 degrees C.
What happens if vancomycin is infused too rapidly?
During or soon after rapid infusion of vancomycin, patients may develop anaphylactoid reactions, including hypotension (see Animal Pharmacology), wheezing, dyspnea, urticaria, or pruritus. Rapid infusion may also cause flushing of the upper body (“red neck”) or pain and muscle spasm of the chest and back.
Why is vancomycin infused slowly?
Slow intravenous administration of vancomycin should minimize the risk of infusion-related adverse effects.
Can vancomycin be mixed in D5W?
“Vancomycin reconstituted intravenous solutions are stable for 14 days at room temperature or refrigeration. Stability of parenteral admixture at room temperature (25°C) or refrigeration temperature (4°C): 7 days. Standard diluent: 500 mg/150 mL D5W; 750 mg/250 mL D5W; 1 g/250 mL D5W.”
Can vancomycin be given with D5W?
How to use VANCOMYCIN-D5W Solution, Piggyback Premix Frozen. This medication is usually given by injection into a vein as directed by your doctor. Each dose should be injected slowly over at least 1 hour. The dosage and length of treatment are based on your medical condition, weight, and response to treatment.
How do you reconstitute vancomycin?
At the time of use, reconstitute the vial with Sterile Water for Injection by adding 10 mL of the diluting solution to the 500-mg vial, 15 mL of the diluting solution to the 750 mg vial, or 20 mL of the diluting solution to the 1-g vial of dry, vancomycin powder. FURTHER DILUTION IS REQUIRED.
How do you reconstitute a vancomycin injection?
At the time of use, reconstitute by adding either 10 mL of Sterile Water for Injection to the 500-mg vial or 20 mL of Sterile Water for Injection to the 1-g vial of dry, sterile vancomycin powder.
How do you dilute vancomycin injections?
At the time of use, reconstitute by adding either 10 mL of Sterile Water for Injection to the 500-mg vial or 20 mL of Sterile Water for Injection to the 1-g vial of dry, sterile vancomycin powder. FURTHER DILUTION IS REQUIRED.
Can you reconstitute vancomycin with NS?
0.5 g (25 mg/mL): one 0.5 g vancomycin vial reconstituted with 10 mL of saline solution + 10 mL of saline solution as diluent, at a flow rate of 0.8 mL/hour. One syringe of 20 mL is required for 24 hours.
How do you calculate vancomycin interval?
Matzke’s method using actual (total) body weight (TBW) was ranked second:
- CLvanco (mL/min) = (CrCl× 0.689) + 3.66.
- Vd = 0.72 L/kg if CrCl is >60 mL/min.
- Vd = 0.89 L/kg if CrCl is 10 to 60 mL/min.
- Vd = 0.9 L/kg if CrCl is less than 10 mL/min.
Why must you reconstitute vancomycin with water for injection?
To reduce microbiological hazards, the solution should be used as soon as practicable after reconstitution. At the time of use, the 500 milligram (500, 000 IU) vial should be reconstituted with 10 mL of Water for Injections. The resulting solution contains vancomycin 50 milligram/mL.