What is meant by colony-stimulating factor?
Listen to pronunciation. (KAH-luh-nee-STIM-yoo-LAY-ting FAK-ter) A substance that stimulates the production of blood cells. Colony-stimulating factors include granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), and promegapoietin.
What does colony stimulating factors stimulate?
Granulocyte–colony-stimulating factor (G-CSF) G-CSF stimulates the production of polymorphonuclear (PMN ) leukocytes, which are necessary for the ingestion and intracellular destruction of bacteria. It is often used to increase neutrophil numbers and decrease infections in patients with non-myeloid malignancies.
What are the four colony stimulating factors?
COLONY STIMULATING FACTORS Family members include macrophage-CSF (M-CSF), granulocyte-CSF (G-CSF), granulocyte/macrophage-CSF (GM-CSF), and interleukin-3 (IL-3).
What are cytokines and colony stimulating factors CSF )?
Granulocyte-macrophage colony-stimulating factor, also known as GM-CSF and CSF2, is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. GM-CSF can be used as a medication to stimulate the production of white blood cells following chemotherapy.
When do you start colony-stimulating factor?
Therapy usually begins 1 to 3 days after chemotherapy ends. Granulocyte colony-stimulating factor is injected into the fatty portion of the skin, usually in the upper arm, thigh, or abdomen. To avoid infection, you should wash your hands before and after the injection and clean the injection site.
Which drugs are considered colony stimulating factors?
Granulocyte colony stimulating factor (G-CSF)
- lenograstim (Granocyte)
- filgrastim (Neupogen, Zarzio, Nivestim, Accofil)
- long acting (pegylated) filgrastim (pegfilgrastim, Neulasta, Pelmeg, Ziextenco) and lipegfilgrastim (Lonquex)
When do you use G-CSF in febrile neutropenia?
Several meta-analyses indicated that primary prophylaxis with G-CSF (i.e., G-CSF administered immediately after cycle 1 of chemotherapy) reduced the risk of febrile neutropenia by 50% in patients with solid tumors, without affecting the rates of tumor response, infection-related death, early-treatment–related death, or …
What are colony stimulating factors quizlet?
Colony-stimulating factors (CSFs) are secreted glycoproteins that bind to receptor proteins on the surfaces of hemopoietic stem cells, thereby activating intracellular signaling pathways that can cause the cells to proliferate and differentiate into a specific kind of blood cell (usually white blood cells.
How are the adverse effects of febrile neutropenia minimized?
Strategies to minimize the adverse effects of febrile neutropenia focus on the use of colony-stimulating factors (CSFs) to reduce the duration and severity of neutropenia, empirical therapy with antibiotics even in the absence of confirmed infection, or both.
Do colonic colonies stimulate febrile neutropenia due to chemotherapy?
Colony stimulating factors for chemotherapy induced febrile neutropenia. The use of CSF in patients with febrile neutropenia due to cancer chemotherapy does not affect overall mortality, but reduces the amount of time spent in hospital and the neutrophil recovery period. It was not clear whether CSF has an effect on infection-related mortality.
Does CSF have an effect on infection-related mortality in chemotherapy-induced febrile neutropenia?
Colony stimulating factors for chemotherapy induced febrile neutropenia The use of CSF in patients with febrile neutropenia due to cancer chemotherapy does not affect overall mortality, but reduces the amount of time spent in hospital and the neutrophil recovery period. It was not clear whether CSF has an effect on infection-related mortality.
What is the prognosis of febrile neutropenia due to cancer chemotherapy?
The use of CSF in patients with febrile neutropenia due to cancer chemotherapy does not affect overall mortality, but reduces the amount of time spent in hospital and the neutrophil recovery period. It was not clear whether CSF has an effect on infection-related mortality.