What is plasma cell mucositis?
Plasma cell mucositis (PCM) is a benign inflammatory condition characterized by dense plasma cell infiltrate in the mucosa close to the orifices. PCM was first reported by Zoon [1] as involving glans penis.
What does a plasma cell look like?
Plasma cells vary in size from 14 to 20 micrometers. They are round-to-ovoid cells containing abundant deep blue cytoplasm with a pale perinuclear area corresponding to the Golgi apparatus. They have a round, eccentrically placed nucleus with coarse chromatin arranged in a clock face (art wheel) pattern.
What is plasma sarcoma?
Solitary bone plasmacytoma is a bone tumor that arises from plasma cells. Plasmacytomas can occur in any bone, but they are most common in the spine. At the Spine Hospital at the Neurological Institute of New York, we specialize in spinal plasmacytomas.
What is plasma in the mouth?
Plasma cell mucositis (PCM) is an unusual plasma cell proliferative disorder of the upper aerodigestive tract. It is a rare disease, and its etiology is not yet known with variable clinical features. Symptoms include dysphagia, oral pain, and swelling.
Where are plasma cells located?
bone marrow
Plasma cells are found in bone marrow, where blood cells are made. Normal bone marrow contains few plasma cells. A person with multiple myeloma often has many abnormal plasma cells (myeloma cells) in the bone marrow. Myeloma cells can form tumours in bones called plasmacytomas.
Are plasma cells cancerous?
Plasma cell neoplasms can be benign (not cancer) or malignant (cancer). There are several types of plasma cell neoplasms. Multiple myeloma and other plasma cell neoplasms may cause a condition called amyloidosis. Age can affect the risk of plasma cell neoplasms.
What causes plasma cell disorder?
Diagnosis. Plasma cell disorders may be suspected because of clinical manifestations most often bone disease, renal failure, and low blood counts, or an incidental finding of elevated serum protein or proteinuria that leads to further evaluation with serum or urine protein electrophoresis.
What is plasma cell stomatitis?
Stomatitis in cats, sometimes called gingivostomatitis, plasma cell stomatitis, or lymphoplasmacytic stomatitis, is a very painful condition affecting the tissues in the mouth. The cause of this condition remains unknown. It may be an immune-mediated process or it may be associated with viral or bacterial causes.
What causes plasma cell gingivitis?
Causes. Plasma cell gingivitis and plasma cell cheilitis are thought to be hypersensitivity reactions to some antigen. Possible sources of antigens include ingredients in toothpastes, chewing gum, mints, pepper, or foods. Specifically, cinnamonaldehyde and cinnamon flavoring are often to blame.
What causes plasma cells?
Plasma cells develop from B lymphocytes (B cells), a type of white blood cell that is made in the bone marrow. Normally, when bacteria or viruses enter the body, some of the B cells will change into plasma cells. The plasma cells make antibodies to fight bacteria and viruses, to stop infection and disease.
What are plasma cells called?
A plasma cell is a type of white blood cell. Also called plasmacyte.
What do plasma cells indicate?
How is plasma cell disease diagnosed?
Which tests are available to monitor plasma cell dyscrasias? Quantitative monoclonal protein tests are used to monitor response to therapy and disease progression. Quantitative tests include serum protein electrophoresis (SPEP), serum free light chain (SFLC), and urine protein electrophoresis (UPEP) measurements.
What Happens When plasma cells become malignant?
This can cause the blood to thicken and keep the bone marrow from making enough healthy blood cells. Multiple myeloma cells also damage and weaken the bone. Plasma cell neoplasms are diseases in which abnormal plasma cells or cells form tumors in the bones or soft tissues of the body.
What is a plasma cell granuloma in gingiva?
INTRODUCTION. Plasma cell granuloma, otherwise known as an inflammatory pseudotumor is an uncommon non-neoplastic lesion considered to be the result of an inflammatory condition. Plasma cell granuloma is very rare in the oral cavity, and more so, on the gingiva. These lesions have no sex predilection and may occur at any age.
What is plasmapheresis granuloma?
Plasma cell granuloma is microscopically characterized by a vascular stroma with reactive inflammatory cells, including plasma cells predominantly and usually surrounded by connective tissue septa. No cytologic abnormalities are usually present.
What is plasma cell granuloma of the lungs?
Abstract. Plasma cell granuloma is a rare benign lesion characterized by the infiltration of plasma cells; primarily occurring in the lungs. It is also seen to occur in the brain, kidney stomach, heart, and so on. In the intraoral region it is seen to involve the tongue, oral mucosa, and gingiva.
Plasma cell mucositis (PCM) is a rare plasma cell proliferative disorder of the upper aerodigestive tract with an unknown etiology. Including the present case, only 22 cases have been reported in the English-language literature. PCM affects adult patients at an average age of 56.6 years.