What does a positive SSB mean?
A positive result for SSA (Ro) or SSB (La) antibodies is consistent with connective tissue disease, including Sjogren syndrome, lupus erythematosus (LE), or rheumatoid arthritis.
What is SSB antibody?
SS-B/La is an extractable nuclear antigen (ENA) composed of a 48-kD protein combined with RNA species. SS-B/La antibodies are found primarily in patients with Sjogren syndrome or lupus erythematosus (LE), where they occur with frequencies of approximately 60% and 15%, respectively.
What is the difference between Sjogren’s syndrome A and B?
SS-A antibodies are found in approximately 60-80% of Sjögren’s syndrome patients. SS-B antibodies are less common, being found in approximately 30-50% of Sjögren’s syndrome patients. SS-A antibodies thus occur commonly by themselves. However, it is very uncommon for SS-B antibodies to occur alone.
What it is SS-A SSB for lupus?
Anti-Ro(SSA) and La(SSB) antibody determinations have become important serologic tests in the evaluation of lupus erythematosus and Sjögren’s syndrome patients. These antibodies appear to identify a group of lupus patients with prominent skin diseases.
Can you have sjogrens with negative SSA and SS-B?
Highlights. Sjögren’s syndrome negative for anti-SSA/SSB antibodies, showed a lower risk of lymphoma. Sjögren’s syndrome negative for anti-SSA/SSB showed a lower prevalence of salivary gland swelling or purpura. Younger patients with anti-SSA/SSB and rheumatoid factor showed the highest risk of lymphoma.
What is the procedure of SSB?
The SSB interview consists of two stages i.e. stage I and stage II. The stage (I) will consist of Officer Intelligence Rating (OIR) and Picture Perception & Description Test (PP & DT). The stage (II) will consist of Interview, Group Testing Officer Tasks, Psychology Tests and the Conference.
What is the criteria for SSB?
The eligibility criteria for the exam is as follows: Candidate must not be more than 35 years of age. Age relaxation of 5 years is applicable for SC/ST candidates. The candidate must be a graduate from any Government recognised University.
Can you have sjogrens with negative SS-A and SS-B?
Can you have Sjogren’s without lupus?
Sjogren’s syndrome can occur alone or in association with other autoimmune diseases, most commonly lupus and rheumatoid arthritis (RA). Several studies have shown various differences between people with SS alone and those with SS and another connective tissue disease.
Does Sjogren’s affect eyesight?
People with Sjogren’s syndrome are much more likely to develop oral thrush, a yeast infection in the mouth. Vision problems. Dry eyes can lead to light sensitivity, blurred vision and corneal damage.
Does having Sjogren’s mean you are immunocompromised?
As a note – not all Sjögren’s patients have compromised immune systems. This specific risk factor is for those who regularly take drugs to suppress the immune system.
Which is worse Sjogren’s or lupus?
The prognosis with SS is generally better than that of other autoimmune diseases such as lupus. Patients with just exocrine gland involvement do not appear to have increased mortality.