What is neointimal hyperplasia?
Neointimal hyperplasia refers to post-intervention, pathological, vascular remodeling due to the proliferation and migration of vascular smooth muscle cells in the tunica intima layer, resulting in vascular wall thickening and the gradual loss of luminal patency which may lead to the return of vascular insufficiency …
What is vascular hyperplasia?
By definition, intimal hyperplasia is an abnormal accumulation of cells in the vascular tunica intima; the cell number is increased because of proliferation and/or migration of vascular wall cells, predominantly smooth muscle cells, often in response to a traumatic stimulus. 1.
What is neointimal thickening?
Neointimal hyperplasia refers to post-intervention, pathological, vascular remodeling due to the proliferation and migration of vascular smooth muscle cells into the tunica intima layer, resulting in vascular wall thickening and the gradual loss of luminal patency which may lead to the return of vascular insufficiency …
What is late stent thrombosis?
Very late stent thrombosis (VLST) refers to ST occurring more than 1 year after the index PCI. 2. VLST is a potentially life-threatening complication of DES that usually presents as acute myocardial infarction (MI) or sudden death.
What does intimal mean?
the innermost membrane or lining of some organ or part, esp. that of an artery, vein, or lymphatic. Derived forms. intimal. adjective.
What is vascular disease?
Vascular Disease (Vasculopathy) Vascular disease (vasculopathy) affects the blood vessels that carry oxygen and nutrients throughout your body and remove waste from your tissues. Common vascular problems happen because plaque (made of fat and cholesterol) slows down or blocks blood flow inside your arteries or veins.
Why does stent thrombosis occur?
The primary factors contributing to stent thrombosis are inadequate stent deployment, incomplete stent apposition, residual stenosis, unrecognized dissection impairing blood flow, and noncompliance with dual antiplatelet therapy (DAPT). Noncompliance with DAPT is the most common cause of stent thrombosis.
What is normal carotid intima-media thickness?
In healthy adults, IMT ranges from 0.25 to 1.5 mm,24 and values >1.0 mm are often regarded as abnormal.
Are all hyperplasia cancerous?
An increase in the number of cells in an organ or tissue. These cells appear normal under a microscope. They are not cancer, but may become cancer.
What is the pathophysiology of neointimal hyperplasia?
Neointimal hyperplasia refers to proliferation and migration of vascular smooth muscle cells primarily in the tunica intima, resulting in the thickening of arterial walls and decreased arterial lumen space. Neointimal hyperplasia is the major cause of restenosis after percutaneous coronary interventions such as…
What is neointimal progression in vascular repair?
Neointimal hyperplasia has broadly been considered as the main process of vascular repair in response to various injuries. Importantly, multiple studies have demonstrated that neointimal progression is a serial scenario of molecular and cellular events.
What is neointimal hyperplasia and restenosis?
Neointimal Hyperplasia and Restenosis Neointimal hyperplasia is the “scar” produced by arteries (and veins) in response to significant vessel injury or altered hemodynamics. While it has certain features in common with atherosclerosis, it is a different pathophysiologic process.
What causes neointimal hyperplasia after carotid transection and anastomosis?
Neointimal hyperplasia after carotid transection and anastomosis surgery is associated with degradation of decorin and platelet-derived growth factor signaling