What is heteroplasia?
Medical Definition of heteroplasia : a formation of abnormal tissue or of normal tissue in an abnormal locality.
Whats Progressive osseous heteroplasia?
Progressive osseous heteroplasia (POH) is an extremely rare disorder characterized by abnormal development of bone in areas of the body where bone is not normally present (heterotopic ossification).
What is heterotopic bone?
Heterotopic ossification (HO) is a diverse pathologic process, defined as the formation of extraskeletal bone in muscle and soft tissues. HO can be conceptualized as a tissue repair process gone awry and is a common complication of trauma and surgery.
Is heterotopic ossification serious?
If the cause of pain or discomfort is not found and treated immediately, serious complications, such as stroke, seizure, organ damage, permanent brain injury or even death, may occur. Autonomic dysreflexia can occur with HO as the abnormal bone growth causes pain that the brain doesn’t recognize because of SCI.
What causes heterotopic bone?
Heterotopic ossification (HO) occurs when bone tissue develops in your soft tissues. Often, people get HO after an injury or major surgery. Genetic HO is rarer and more severe. In HO, you develop a bony, painful lump underneath your skin.
How do you get rid of heterotopic ossification?
In the case of heterotopic ossification, the only effective treatment is excision, also called resection. Dr. Nwachukwu will often delay surgical excision for 5-6 months following the initial hip trauma and/or inciting surgery, allowing the bone growth to mature and for a distinct fibrous capsule to develop.
What is treatment for heterotopic ossification?
Usually, treatment will include gentle range of motion of the joints and some physical therapy. Your doctor may also prescribe medications to slow down or stop the abnormal growth of bone. When HO severely affects your movement or causes excruciating pain, surgery may be needed.
Does heterotopic ossification go away?
Does heterotopic ossification go away? Sometimes. People with nongenetic HO often have a full recovery. Often, HO that develops after an injury goes away with nonsurgical treatment such as rest, ice and light stretching.
How do you fix heterotopic ossification?
How is heterotopic ossification treated?
- Medications such as corticosteroids to treat HO flare-ups in people with genetic heterotopic ossification.
- Physical therapy to increase range of motion and decrease pain.
- Surgery to remove heterotopic ossification that causes severe pain or restrictions in your daily function.
What is pro-progressive osseous heteroplasia?
Progressive osseous heteroplasia is a disorder in which bone forms within skin and muscle tissue. Bone that forms outside the skeleton is called heterotopic or ectopic bone.
Where does ectopic bone formation occur in osseous heteroplasia?
In progressive osseous heteroplasia, ectopic bone formation begins in the deep layers of the skin (dermis and subcutaneous fat) and gradually moves into other tissues such as skeletal muscle and tendons. The bony lesions within the skin may be painful and may develop into open sores (ulcers).
What causes abnormal bone growth in heterotopic ossification?
Abnormal Excess Bone Growth in Heterotopic Ossification 1 Symptoms. The most common symptom of heterotopic ossification is stiffness of a joint. 2 Causes. Heterotopic ossification occurs when the body gets signals mixed up, and bone cells begin to create new bone outside of the normal skeleton. 3 Treatment. 4 Prevention.
Can heterotopic bone formation be prevented?
In patients at high risk for the development of heterotopic bone formation, there are several treatments that have been used to prevent the development of excess bone. Certain medications, including high doses of nonsteroidal anti-inflammatory medications ( NSAIDs ), have been shown to decrease the development of heterotopic bone. 2