What is the medication Sargramostim used for?
Sargramostin is used to decrease the chance of infection in people who have acute myelogenous leukemia (AML; a type of cancer of the white blood cells) and are receiving chemotherapy medications that may decrease the number of neutrophils (a type of blood cell needed to fight infection).
Which of the following are indications for Sargramostim Leukine?
LEUKINE is indicated for the acceleration of myeloid reconstitution following autologous peripheral blood progenitor cell (PBPC) or bone marrow transplantation in adult and pediatric patients 2 years of age and older with non-Hodgkin’s lymphoma (NHL), acute lymphoblastic leukemia (ALL) and Hodgkin’s lymphoma (HL).
What is another name for Sargramostim?
Leukine is the trade name for sargramostim. GM-CSF is another name for sargramostim. In some cases, health care professionals may use the trade name leukine or other names GM-CSF when referring to the generic drug name sargramostim. Drug type: Sargramostim is a biologic response modifier.
What is Filgrastim used for?
Filgrastim injection is used to treat neutropenia (low white blood cells) that is caused by cancer medicines. It is a synthetic (man-made) form of a substance that is naturally produced in your body called a colony stimulating factor. Filgrastim helps the bone marrow to make new white blood cells.
What are the side effects of filgrastim?
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- Bleeding gums.
- bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site.
What type of drug is Leukine?
What is Leukine and how is it used? Leukine is a prescription medicine used to treat the symptoms of Leukemia, Bone Marrow Transplant, and Pre-Chemotherapy Blood Cell Collection. Leukine may be used alone or with other medications. Leukine belongs to a class of drugs called Hematopoietic Growth Factors.
When is filgrastim contraindicated?
Filgrastim is contraindicated in patients with allergic reactions to E. coli-derived proteins, filgrastim, or any component of the product.
What is common side effect of filgrastim?
fever, abdominal pain, back pain, feeling unwell. swelling of stomach area or other swelling, decreased urination, trouble breathing, dizziness, tiredness. rash, hives, itching, swelling of the face, eyes, or mouth, wheezing, shortness of breath. unusual bleeding or bruising, purple markings under the skin, red skin.
When should filgrastim not be given?
However, do not use it within 24 hours before you begin another chemotherapy. Allow the medicine to warm to room temperature for 30 minutes before you inject it. If the liquid in the prefilled syringe or vial has changed color, looks cloudy, or if you see particles in it, do not use it.
What are the contraindications of epoetin alfa?
Epoetin alfa is contraindicated in patients with serious allergic reactions, such as anaphylactic reactions, angioedema, bronchospasm, skin rash, and urticaria, to the product. Immediately and permanently discontinue epoetin alfa and administer appropriate therapy if a hypersensitivity reaction occurs.
Why is Leukine used?
Leukine (sargramostim) is an injectable medication that can lower your risk of infection when you have low white blood cells. It’s also used during bone marrow transplant therapy.
How do you inject Leukine?
This medication is given by injection under the skin or into a vein as directed by your doctor, usually once a day. The dosage is based on your medical condition, body size, lab tests, and response to treatment.
What is the indication of erythropoietin?
ESAs are generally indicated in conditions where there is impaired red blood cell production. The two primary FDA-approved indications for ESAs are anemia secondary to chronic kidney disease and chemotherapy-induced anemia in patients with cancer.
What is the efficacy of sargramostim therapy?
Sargramostim therapy has demonstrated efficacy in shortening the time to neutrophil recovery and in reducing the duration of antibiotic use, infection, and hospitalization. Following peripheral blood stem cell (PBSC) transplantation.
How do you calculate dose of sargramostim?
Dose based on weight as follows: sargramostim 12 micrograms (mcg)/kg subcutaneously once daily in patients weighing less than 15 kg; sargramostim 10 mcg/kg subcutaneously once daily in patients weighing 15 to 40 kg; OR sargramostim 7 mcg/kg subcutaneously once daily in patients weighing greater than 40 kg.
Is sargramostim an orphan drug?
NOTE: Sargramostim has been designated as an orphan drug by the FDA for the treatment of individuals acutely exposed to myelosuppressive doses of radiation.
What is the difference between GM CSF and sargramostim?
Chemistry. Sargramostim is a recombinant version of GM-CSF, which is a glycoprotein made of 127 amino acids; sargramostim is mixture of three versions of GM-CSF that have molecular weights of 19,500, 16,800 and 15,500 Daltons. It is manufactured in yeast.