How does amodiaquine work?
They depress respiration and cause diplopia, dizziness and nausea. The mechanism of plasmodicidal action of amodiaquine is not completely certain. Like other quinoline derivatives, it is thought to inhibit heme polymerase activity. This results in accumulation of free heme, which is toxic to the parasites.
What are the side effect of amodiaquine?
Side effect(s) of Amodiaquine Most Common – Nausea, vomiting, itching, stomach upset and headache. Miscellaneous – Loss of vision, skin rash, muscle pain, loss hearing and graying of hair. Other Precautions : * Avoid excess dosage.
What are antimalarial drugs used for?
Antimalarial drugs are used for the treatment and prevention of malaria infection. Most antimalarial drugs target the erythrocytic stage of malaria infection, which is the phase of infection that causes symptomatic illness (figure 1).
What are the side effects of artesunate?
Common side effects of Artesunate include: Loss of appetite on days 1-2. Dizziness on days 1-2. Nausea on days 1-2….Additional Side Effects of Artesunate can include:
- Hives.
- Rash.
- Hemoglobinuria.
- Seizures.
- Neuropsychiatric reactions.
- Reversible neurologic changes.
How long does amodiaquine stay in the body?
The pharmacokinetic properties of each drug are relatively well characterized: lumefantrine and its metabolite desbutyl-lumefantrine have terminal elimination half-lives of 1–10 days [1, 13,14,15,16], while desethylamodiaquine, the active metabolite of amodiaquine, has a half-life of 4–10 days [1, 17,18,19,20,21,22].
Does amodiaquine cause weakness?
(Among 3113 patients treated with artesunate and amodiaquine for falciparum malaria in 8 controlled trials, common treatment emergent side effects were cough [33%], anorexia [17%], vomiting [15%], diarrhea [17%], pruritus [18%] and weakness [16%]; 4 patients [1%] developed jaundice, but no details provided).
Are anti malaria tablets safe?
Side effects which affect fewer than one in 100 people can include hair loss, palpitations and a red or sore mouth. Rarely, it may cause changes to your blood which would show up in a blood test, so you should always tell your doctor if you are using antimalarials and need a blood test.
How many days it will take to recover from malaria?
With proper treatment, symptoms of malaria usually go away quickly, with a cure within two weeks. Without proper treatment, malaria episodes (fever, chills, sweating) can return periodically over a period of years. After repeated exposure, patients will become partially immune and develop milder disease.
Is amodiaquine same as chloroquine?
Amodiaquine is being used in India for presumptive treatment as an alternative to chloroquine in areas with chloroquine resistant P. falciparum. Keeping in view the toxicity of amodiaquine, studies have been undertaken to evaluate the advantage of the drug over chloroquine in the treatment of P. falciparum malaria.
How long do I take malaria tablets for?
Begin 1-2 days before travel, daily during travel, and for 7 days after leaving. Adults: 300 mg base (500 mg salt), once/week. Children: 5 mg/kg base (8.3 mg/kg salt) (maximum is adult dose), once/week. Begin 1-2 weeks before travel, once/week during travel, and for 4 weeks after leaving.
Is artesunate an antibiotic?
By compromising NO-mediated protection from antibiotics and triggering harmful hydrogen peroxide burst, artesunate may serve as a promising antibiotic synergist for killing the multidrug resistant pathogenic bacteria.
What food should be avoided in malaria?
Foods that need to be avoided by malaria patients are:-
- A high fibre foods such as whole grain cereals, green leafy vegetables, thick skin fruits, etc.
- Fried foods, processed foods, junk foods, oily and spicy foods, pickle, etc.
- Excess intake of tea, coffee, cocoa and other caffeinated beverages, etc.