What is melphalan used to treat?
Melphalan injection is used to treat multiple myeloma (bone marrow cancer) before receiving a stem cell transplant (conditioning treatment). Melphalan belongs to the group of medicines called alkylating agents (cancer medicines).
What is the latest treatment for myeloma?
The latest approval is for the combination of daratumumab plus hyaluronidase-fijh (Darzalex Faspro) plus carfilzomib (Kyprolis) and the steroid dexamethasone for the treatment of adults with relapsed or refractory multiple myeloma who received one to three prior treatments.
How do you administer melphalan?
Melphalan injection comes as a powder to be mixed with liquid to be slowly injected intravenously (into a vein) over 15 to 30 minutes by a doctor or nurse in a medical facility.
What type of chemo is melphalan?
Drug type: Melphalan is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. This medication is classified as an “alkylating agent.” (For more detail, see “How this drug works” section below).
When does hair grow back after melphalan?
Your hair will start to grow back once you are finished with treatment, but it may take six to 12 months to grow back completely.
What is success rate of stem cell transplant?
The popularity of stem cell treatments has significantly increased, thanks to its high effectiveness and recorded success rates of up to 80%. It is a modern type of regenerative medical treatment that uses a unique biological component called stem cells.
What type of drug is melphalan?
Drug type: Melphalan is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. This medication is classified as an “alkylating agent.” (For more detail, see “How this drug works” section below). Used in some conditioning regimens prior to bone marrow transplant
Does melphalan cause anaphylaxis?
Melphalan. Hypersensitivity reactions, including anaphylaxis, have occurred in approximately 2% of patients who received the IV formulation. Melphalan is leukemogenic in humans. Melphalan produces chromosomal aberrations in vitro and in vivo and, therefore, should be considered potentially mutagenic in humans.
What are the side effects of melphalan hydrochloride for injection?
As with other nitrogen mustard drugs, excessive dosage will produce marked bone marrow suppression. Bone marrow suppression is the most significant toxicity associated with Melphalan Hydrochloride for Injection in most patients.
What should be included in patient education about melphalan toxicity?
Patients should be informed that the major acute toxicities of Melphalan are related to bone marrow suppression, hypersensitivity reactions, gastrointestinal toxicity, and pulmonary toxicity. The major long-term toxicities are related to infertility and secondary malignancies.