What is korlym used for?
Korlym® (mifepristone) is a cortisol receptor blocker indicated to control hyperglycemia secondary to hypercortisolism in adult patients with endogenous Cushing’s syndrome who have type 2 diabetes mellitus or glucose intolerance and have failed surgery or are not candidates for surgery.
How long does it take for korlym to work?
60% of patients had a 25% or greater reduction in blood sugar, with improvement seen as early as 6 weeks after initial treatment. A 1.1% reduction in HbA1c was seen by week 24 of treatment.
What are the side effects of korlym?
The most common side effects of Korlym include:
- Nausea.
- Fatigue.
- Vomiting.
- Decreased appetite.
- Pain in your arms and legs (arthralgia)
- Swelling of your arms and legs. (peripheral edema)
- Headache.
- Dizziness.
How long do you take korlym?
Dosing & Monitoring
- The recommended starting dose of Korlym is 300 mg/day1
- The dose may be increased by 300 mg (to a maximum of 1200 mg daily) every 2 to 4 weeks as needed.
Is there a generic for korlym?
mifepristone tablet;oral Ask your health care provider for advice if you are unsure about the online purchase of any medication. See also: Generic Drug FAQ.
Does mifepristone cause weight loss?
Clinically meaningful weight loss achieved during a 24-week study of mifepristone for CS persisted for two additional years in patients who remained on therapy. Long-term treatment with mifepristone appears to have a beneficial effect on weight in patients with endogenous CS.
Is there a generic for Korlym?
Who makes Korlym?
Corcept Therapeutics, a Silicon Valley-based drug company, began marketing Korlym six years ago as a specialty drug for about 10,000 rare-disease patients such as Edwin.
Who manufactures korlym?
What is endogenous Cushing’s syndrome?
Your body’s own overproduction (endogenous Cushing syndrome) The condition can be due to your body producing either too much cortisol or too much adrenocorticotropic hormone (ACTH), which regulates cortisol production. In these cases, Cushing syndrome may be related to: A pituitary gland tumor (pituitary adenoma).
How will I feel after mifepristone?
Some people feel nauseous or start bleeding after taking mifepristone, but it’s not common. Your doctor or nurse may also give you antibiotics to take to prevent infection.
Will it pain after taking mifepristone?
Previous studies of medical abortion with mifepristone and a prostaglandin have reported percentages of subjects who experience cramping and/or bleeding relative to prostaglandin use.
Does Korlym work for hyperglycemia?
Improving Measures. That Matter. Korlym® (mifepristone) is a cortisol receptor blocker indicated to control hyperglycemia secondary to hypercortisolism in adult patients with endogenous Cushing’s syndrome who have type 2 diabetes mellitus or glucose intolerance and have failed surgery or are not candidates for surgery.
What are the side effects of Korlym?
The most common side effects of Korlym include nausea, fatigue, headache, low potassium in the blood, pain in arms and legs (arthralgia), vomiting, swelling of arms and legs (peripheral edema), high blood pressure, dizziness, decreased appetite, and thickening of the lining of the uterus (endometrial hypertrophy).
What is the name of the drug Korlym?
Korlym (mifepristone) is a cortisol receptor blocker for oral administration. The chemical name of mifepristone is 11β- (4-dimethylaminophenyl)-17β-hydroxy-17α- (1-propynyl)-estra-4, 9-dien-3-one.
What is the goal of treatment with Korlym®?
The goal of treatment with Korlym® is to decrease the symptoms of excess cortisol activity. Korlym does not decrease cortisol levels. The production of cortisol is part of an important process that impacts many systems in your body. Cortisol binds to, and activates, cortisol receptors, which are present in almost every cell of your body.