What is the pathophysiology of Goodpasture syndrome?
Pathophysiology. Goodpasture syndrome is due to circulating autoantibodies directed at the glomerular basement membrane. The resulting crescentic glomerulonephritis is the result of the antigen-antibody complexes that form at the basement membrane.
What is the cause of tissue injury in a patient with Goodpasture syndrome?
Goodpasture syndrome attacks collagen in the glomerular basement membrane (GBM) of the kidneys. These anti-GBM antibodies also attack collagen in the lung’s air sacs, destroying the tissues and leading to bleeding and difficulty breathing.
Is Goodpasture’s syndrome a nephritic syndrome?
Crescentic or rapidly progressive glomerulonephritis (RPGN) is characterized by the nephritic syndrome presenting with the clinical picture of sudden and severe acute renal failure. However, RPGN does not have a specific etiology. It may occur due to: Anti-GBM antibody-mediated disease (e.g., Goodpasture syndrome)
What is anti-GBM glomerulonephritis?
Anti-GBM disease is a disorder in which your body’s immune system creates antibodies that attack your kidneys and lungs. As a result, you may develop one or both of these conditions. glomerulonephritis linkâinflammation of the glomeruli, tiny units in your kidney that filter wastes and extra fluid from your blood.
How does Goodpasture’s syndrome affect the kidneys?
Normally, the immune system makes antibodies to fight off germs. But with Goodpasture syndrome, the immune system mistakenly makes antibodies that attack the lungs and kidneys. This condition can quickly progress to an inflammation of the kidneys (glomerulonephritis) and kidney failure.
What is the cause of rapidly progressive glomerulonephritis in Goodpasture syndrome?
The most common occurrence is in systemic lupus erythematosus. Other associated diseases include inflammatory bowel disease, sclerosing cholangitis, autoimmune hepatitis, rheumatoid arthritis, and Felty syndrome.
How does Goodpasture’s syndrome affect lungs?
Although Goodpasture syndrome may cause life-threatening bleeding in the lungs, it usually does not result in long-term lung damage. The most serious consequence of Goodpasture syndrome is kidney failure, which may require either dialysis or a kidney transplant.
What is the mechanism of glomerulonephritis?
Acute glomerulonephritis (GN) comprises a specific set of renal diseases in which an immunologic mechanism triggers inflammation and proliferation of glomerular tissue that can result in damage to the basement membrane, mesangium, or capillary endothelium.
What is the major cause of glomerulonephritis?
What causes acute glomerulonephritis? The acute disease may be caused by infections such as strep throat. It may also be caused by other illnesses, including lupus, Goodpasture’s syndrome, Wegener’s disease, and polyarteritis nodosa. Early diagnosis and prompt treatment are important to prevent kidney failure.
What is the pathogenesis of glomerular disease?
The pathogenesis of glomerular diseases are considered to be the result of interplay between genetics and unfavourable environmental conditions. Here, genetic factors may predispose certain individuals to develop immune responses that can lead to glomerulonephritis and inflammatory and non-inflammatory immune …
What happens to the kidney in acute glomerulonephritis?
Glomerulonephritis is inflammation and damage to the filtering part of the kidneys (glomerulus). It can come on quickly or over a longer period of time. Toxins, metabolic wastes and excess fluid are not properly filtered into the urine. Instead, they build up in the body causing swelling and fatigue.
What is the main etiological factor of acute glomerulonephritis?
What is the etiology of glomerulonephritis?
Glomerulonephritis can be caused by various of factors including: Toxins or medicines. Viral infections, such as HIV, hepatitis B and C viruses. IgA nephropathy. Lupus-related kidney inflammation.
Is Goodpasture syndrome an autoimmune disease?
Summary Summary. Goodpasture syndrome is an autoimmune disease that affects the lungs and kidneys and is characterized by pulmonary alveolar hemorrhage (bleeding in the lungs) and a kidney disease known as glomerulonephritis.
What is the prognosis of Goodpasture syndrome (glomerulonephritis)?
Patients presenting with Goodpasture syndrome (both glomerulonephritis and pulmonary hemorrhage) may be critically ill on presentation. Urgent hemodialysis often is needed for standard indications, and intubation for respiratory failure may be necessary.
What are the long-term effects of Goodpasture’s syndrome?
Goodpasture’s Syndrome may cause life-threatening bleeding in the lungs, but does not usually cause long-term damage in that area. The harm done to your kidneys, however, can result in kidney failure. You may need either dialysis or a kidney transplant. If your kidney function is affected, you may:
What are the symptoms of glomerulonephritis?
As a result, if you have this disease, you may start to experience fatigue, weakness and loss of appetite. However, the disease may quickly progress and you may bleed from the lungs and cough up blood. It may also lead to inflamed kidneys (glomerulonephritis).