What are the causes of hypertriglyceridemia?
Hypertriglyceridemia has many causes, including familial and genetic syndromes, metabolic disease, and drugs. Risks appear to include diet, stress, physical inactivity, and smoking.
What happens in hypertriglyceridemia?
Hypertriglyceridemia, both in the metabolic syndrome and in type 2 diabetes, results from increased plasma concentrations of VLDL, with or without chylomicronemia;9 deficient lipoprotein lipase activity; increased cholesteryl ester transfer protein activity; and increased flux of free fatty acids to the liver.
What is the meaning of hypertriglyceridemia?
Hypertriglyceridemia refers to an elevated level of triglycerides (a type of lipid) in the bloodstream, a condition that increases the risk of coronary artery disease.
Is hypertriglyceridemia serious?
Individuals with severe hypertriglyceridemia (SHTG) have triglyceride levels more than three times the normal level. SHTG can lead to multiple serious conditions, including cardiovascular disease (CVD) and acute pancreatitis.
Can hypertriglyceridemia be cured?
Although the rare inherited disorders of severe hypertriglyceridemia require heroic restrictions in dietary fat, most elevated triglycerides can be controlled, at least partially, by a program of diet, exercise, and weight loss.
How can I reduce my triglyceride level?
What’s the best way to lower triglycerides?
- Exercise regularly. Aim for at least 30 minutes of physical activity on most or all days of the week.
- Avoid sugar and refined carbohydrates.
- Lose weight.
- Choose healthier fats.
- Limit how much alcohol you drink.
What is hyper hypertriglyceridemia and why is it important?
Hypertriglyceridemia is an important marker of increased levels of highly atherogenic remnant-like particles. The importance of lowering plasma levels of triglycerides (TG) has been called into question many times, but currently it is considered an integral part of residual cardiovascular risk reduction strategies.
Why are TG levels high in HTG patients?
Second, the genetic pool of adult HTG patients is enriched for rare heterozygous large-effect mutations within genes that are associated with elevated plasma TG levels [3,4,5,6]. Finally, secondary factors can push a genetically susceptible individual over the edge metabolically, resulting in clinical presentation [1].
Are hypertriglyceridemic metabolic products atherogenic?
Although there are a number of severely hypertriglyceridemic animals, especially genetically modified mice, these animals develop only early-stage lesions ( 138, 139 ). In contrast, there is no doubt that metabolic products of triglyceride-rich lipoproteins are atherogenic ( 140 – 142 ).