What is Spheronization process?
Spheronization is the process where extrudates (the output from an extruder) are shaped into small rounded or spherical granules. In practice these usually vary in size from 0.4 to about 3.0 mm. The use of these spheroids can be relevant for a wide variety of industries.
What is pellet in pharmacy?
Pellet (or bead) technology allows a variety of different drug delivery profiles to be achieved by coating a ‘core’ of drug and excipient with various polymers. The drug cores are generally spheroidal in shape and have a diameter in the range of 300 to 1,700 µm.
How are pellets made in pharmaceutical industry?
In pharmaceutical industries, pellets are multiparticulate dosage form which was formed by the agglomeration of fine powdered excipient and drugs together that leads to the formation of small free flowing spherical or semi spherical particles. This technique is called as pelletization process.
What is pelletization process?
Pelletizing is the process of compressing or molding a material into the shape of a pellet. A wide range of different materials are pelletized including chemicals, iron ore, animal compound feed, plastics, waste materials, and more.
What is extrusion and Spheronization?
Extrusion spheronization is a multiple process of wet mass extrusion followed by spheronization to produce uniform size spherical particles, called as spheroids, pellets, beads or matrix pellets depending upon the material as well as process used for extrusion spheronization1.
What is green ball in pelletization?
Green pellets are made by combining moist ore with a binder and rolling it into balls using either a pelletizing disk or a pelletizing drum. From: Iron Ore, 2015.
What are pellets explain in detail about pelletization process and its evaluation?
Pellets are the multi-unit dosage forms which offer improved safety and efficacy of the active ingredients with excellent flow properties which is then fabricated in single dosage form. Pelletization technique produces more spherical pellets and offers more advantages than granulation process.
What is the difference between pellet and sinter?
Sinter and pellets are agglomerated forms of iron ore, both suitable for use as blast furnace burden materials. The principle difference between sinter and pellets arises from the type of raw materials used in their preparation and the nature of the sinter and pelletizing agglomeration processes.
What are the different types of extrusion processes?
There are different types of extrusion processes, however, including cold, hot, friction and micro.
- Cold Extrusion. With cold extrusion, metal is forced through the die while at or near room temperature.
- Hot Extrusion.
- Friction Extrusion.
- Micro Extrusion.
How many types of extrusion process are there?
Extrusion is classified in general into four types. They are: Direct extrusion, indirect extrusion, impact extrusion and hydrostatic extrusion. In extrusion process, the billet is placed in a container, pushed through the die opening using a ram and dummy block. Both ram and billet move.
What is the binding ingredients used in pelletization?
Five clay binders were evaluated on a pilot plant pellet mill. The basal ration contained 70% ground corn, 30% SBM, and vegetable oil added last. A positive control was mixed without oil. Each of five clays was added on top of the ration at a level of 2%.
What is extrusion process in manufacturing?
Extrusion is a process where a material undergoes plastic deformation by the application of a force causing that material to flow through an orifice or die. The material adopts the cross-sectional profile of the die and if the material has suitable properties, that shape is retained in the final extrudate.
What is extrusion manufacturing process?
What is iron ore pelletization?
Iron ore fines are agglomerated into pellets and then indurated using a furnace to create iron ore pellets. These are typically fed to a blast furnace or DRI plant as part of the process to make steel. Expertise. Designed and supplied the largest straight grate systems in the world.
What is meant by pelletization?
… Pelletization is a form of the process through agglomeration that transforms granules of bulk drug powders into pellets (Kandukuri et al., 2009). It is frequently denoted as a size-amplification procedure in which agglomerates of narrow size (0.5-2.0 mm mean size) called pellets are formed (Deb and Ahmed, 2013).
What are pellets in the pharmaceutical industry?
In the pharmaceutical industry, pellets can be defined as small, free-flowing, spherical particulates manufactured by the agglomeration of fine powders or granules of drug substances and excipients using appropriate processing equipment.
What are the advantages of custom pelletization in the pharmaceutical industry?
Pelletization has gained a great interest in recent years due to its various advantages over other similar techniques; such as uniformity of dose and flexibility in dosage form design. There are a number of pelletization techniques currently used by pharmaceutical industry.
What is the process of agglomeration and pelletization?
Pelletization is an agglomeration process that converts fine powders or granules of bulk drugs and excipients into small, free-flowing semi-spherical units. Extrusion spheronization is widely utilized in the formulation of sustained-release, controlled-release delivery systems.