Can you take Zoloft while taking tamoxifen?
Other SSRI medications, such as citalopram (Celexa), escitalopram (Lexapro), venlafaxine (Effexor) and sertraline (Zoloft) are considered to be less potent inhibitors of CYP2D6. If taken with tamoxifen, these CYP2D6 inhibitors could possibly decrease the available amount of the active metabolite (endoxifen).
Can you take antidepressants with tamoxifen?
A recent study published in the British Medical Journal provides evidence that antidepressants which are potent inhibitors of CYP2D6 enzymes may decrease the effectiveness of tamoxifen and may result in worse outcomes.
What drugs are incompatible with tamoxifen?
Blossom Paravattil, Megan Cole, and Danielle Shapiro, MD, MPH, Cancer Prevention and Treatment Fund
| Classes of drugs | Drugs that are likely to interfere with tamoxifen |
|---|---|
| Cardiac Drugs | Cardioquin and Ticlid |
| Allergy medications | Benadryl (diphenhydramine), Unisom (doxylamine), Dimetapp (Brompheniramine), Tagamet (cimetidine) |
What is the best antidepressant to take with tamoxifen?
Venlafaxine has little or no effect on the metabolism of tamoxifen and may be considered the safest choice of antidepressants. Desvenlafaxine is not metabolized by the P450 system and may consequently be another option.
What SSRI to avoid when taking tamoxifen?
Caution should be used when it is taken along with antidepressant medications, as some of them interfere with the way tamoxifen works at decreasing the risk of breast cancer recurrence. Antidepressants such as Paxil or Prozac should be avoided, while others, such as Celexa or Lexapro, may be a safer option.
Which antidepressant is best with tamoxifen?
Does Zoloft increase estrogen?
In another study, Hansen et al. found that fluoxetine, paroxetine, citalopram, escitalopram, sertraline and fluvoxamine all increase the estrogen/ androgen ratio, which is an indicator of aromatase activity [66] .
Does taking tamoxifen cause anxiety?
While studies have shown tamoxifen significantly improves survival rates for women with breast cancer by blocking the effects of estrogen, clinical evidence suggests the drug increases rates of anxiety and the incidence of hot flashes, both of which may result from reduced action of estrogen.
Is Zoloft good for hormones?
They found that Prozac (fluoxetine), Paxil (paroxetine) and Zoloft (sertraline) all made the enzyme work more efficiently, thus enhancing brain levels of the anxiety-relieving hormone.
Can Zoloft affect your hormones?
Acute administration of SSRIs increases the secretion of several hormones, but chronic treatment with SSRIs does not alter basal blood levels of hormones. However, adaptive changes are induced by long-term treatment with SSRIs in serotonergic, noradrenergic and peptidergic neural function.
Does tamoxifen affect serotonin?
These data show that tamoxifen administration increased anxiety levels, but the affect was not associated with differences in central levels of the serotonin tone.
Does Zoloft increase estrogen levels?
Can I take Zoloft and estrogen?
Interactions between your drugs No interactions were found between estradiol and Zoloft. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Is 200 mg of Zoloft too much?
The typical starting dose is 50 mg per day. Your doctor will slowly increase your dose every week, as needed. The maximum dose is 200 mg per day.
What is tamoxifen used for?
What is tamoxifen? Tamoxifen blocks the actions of estrogen, a female hormone. Certain types of breast cancer require estrogen to grow. Tamoxifen is used to treat some types of breast cancer in men and women. It is also used to lower a woman’s chance of developing breast cancer if she has a high risk (such as a family history of breast cancer).
What are the side effects of tamoxifen?
Tamoxifen is also used to lower a woman’s chance of developing breast cancer if she has a high risk (such as a family history of breast cancer). Taking tamoxifen may increase your risk of uterine cancer, liver cancer, stroke, or a blood clot in the lung, which can be fatal.
How many mg tamoxifen can you take for breast cancer?
Tamoxifen dosing information. Usual Adult Dose for Breast Cancer: For the treatment of metastatic breast cancer in women and men: 20 to 40 mg orally Dosages greater than 20 mg should be given in divided doses (morning and evening).
How is tamoxifen supplied?
How is Tamoxifen Supplied. to lower the chance of getting invasive (spreading) breast cancer in women who had surgery and radiation for ductal carcinoma in situ (DCIS). DCIS means the cancer is only inside the milk ducts. to treat breast cancer in women after they have finished early treatment.