Table of Contents
What is cytarabine liposome injection?
DepoCyt® (cytarabine liposome injection) is a sterile, injectable suspension of the antimetabolite cytarabine, encapsulated into multivesicular lipid-based particles.
How does cytarabine work?
How it works. Cytarabine is a type of chemotherapy drug. It kills cancer cells by stopping them from making and repairing DNA that they need to grow and multiply.
How is cytarabine liposomal administered?
How Cytarabine Liposomal Is Given: Liposomal cytarabine is given is by intraventricular or intrathecal infusion. This method is used when drugs need to reach the cerebrospinal fluid (CSF) the fluid that is surrounding the brain and spinal cord, the drug is infused directly into the spinal fluid.
In which position should the nurse place a patient following the administration of cytarabine liposomal?
Liposomal Cytarabine Following intrathecal administration by lumbar puncture, patient should lie flat for 1 hour.
Is cytarabine an anthracycline?
Cytarabine-anthracycline based intensive induction chemotherapy (IC) remains the standard of care for remission induction among fit patients with newly diagnosed acute myeloid leukemia (AML) in the United States (US).
Does cytarabine cause diarrhea?
These are less common side effects (occurring in about 10-29%) for patients receiving cytarabine: Diarrhea. Loss of appetite. Skin rash, redness and itching.
What is the half life of cytarabine?
Human Pharmacology Following rapid intravenous injection of cytarabine labeled with tritium, the disappearance from plasma is biphasic. There is an initial distributive phase with a half-life of about 10 minutes, followed by a second elimination phase with a half-life of about 1 to 3 hours.
Is cytarabine compatible with sodium bicarbonate?
The results of this study indicate that sodium bicarbonate 50 mEq/L in the intravenous solution containing cytarabine has no effect on the chemical stability of cytarabine for at least one week at room temperature or in the refrigerator.
Why is cytarabine given Intrathecally?
Cytarabine may be given as an infusion into the vein (intravenous or IV). Another method it is given is by intrathecal infusion. This method is used when drugs need to reach the cerebrospinal fluid (CSF) the fluid that is surrounding the brain and spinal cord, the drug is infused directly into the spinal fluid.
What is Vyxeos chemotherapy?
About Vyxeos Vyxeos (daunorubicin and cytarabine liposome for injection) is a chemotherapy treatment option specifically indicated for the treatment of adults with newly diagnosed therapy-related acute myeloid leukemia (t-AML) or AML with myelodysplasia-related changes (AML-MRC).
What do Hypomethylating agents do?
A hypomethylating agent (or demethylating agent) is a drug that inhibits DNA methylation: the modification of DNA nucleotides by addition of a methyl group.
How is cytarabine excreted?
Elimination Cytarabine and its inactive metabolite are excreted in urine. Clearance of intrathecal dose is by CSF bulk flow and diffusion to plasma; CSF levels of deaminase are low. The side effects reported below were from conventional dose therapy, unless specified as high dose.
What is the half-life of cytarabine?
How does cytarabine stop DNA replication?
It does this by inhibiting the production of the cells’ genetic material, DNA and RNA. Both DNA and RNA are needed for growth and multiplication of cells. Cytarabine causes a deficiency of DNA and RNA in the cancer cells, and this causes the cells to grow in an unbalanced way, resulting in the death of the cells.
Can cytarabine be given subcutaneously?
DOSAGE AND ADMINISTRATION Cytarabine Injection (non-preserved) can be administered by intravenous injection or infusion, subcutaneously, or intrathecally.
Is intrathecal chemo effective?
Intrathecal chemotherapy is more effective than oral or IV chemotherapy for cancer that’s spread to the central nervous system. Your doctor can give you specific information about your type of cancer, prognosis, and available treatment options.
What is the composition of Depocyt?
DepoCyt is available in 5 mL, ready-to-use, single-use vials containing 50 mg of cytarabine. DepoCyt is formulated as a sterile, non-pyrogenic, white to off-white suspension of cytarabine in Sodium Chloride 0.9% w/v in Water for Injection. DepoCyt is preservative-free.
How many milligrams of Depo is in a vial?
DepoCyt is available as a single-dose vial containing 50 mg/5 mL (10 mg/mL) of cytarabine. DepoCyt is formulated as a sterile, non-pyrogenic, white to off-white suspension of cytarabine liposomes in 0.9% w/v sodium chloride in water for injection.
What is the pH level of Depo-cyt?
The pH of the product falls within the range from 5.5 to 8.5. DepoCyt® (cytarabine liposome injection) is indicated for the intrathecal treatment of lymphomatous meningitis. DepoCyt is a cytotoxic anticancer drug and, as with other potentially toxic compounds, caution should be used in handling DepoCyt.
How do you dose Depo cyt 50 mg?
Dosing Regimen. For the treatment of lymphomatous meningitis, DepoCyt 50 mg (one vial of DepoCyt) is recommended to be given according to the following schedule: Patients should be started on dexamethasone 4 mg twice a day either by mouth or intravenously for 5 days beginning on the day of DepoCyt injection.