What are coagulation factor concentrates?
Clotting factor concentrate prophylaxis aims to preserve joint function by converting severe hemophilia (factor VIII or IX less than 1%) into a clinically milder form of the disease. Prophylaxis has long been used in Sweden, but not universally adopted because of medical, psychosocial, and cost controversies.
What are factor VIII concentrates?
Factor VIII concentrate is used to treat hemophilia A. Vials of factor concentrate are labeled with the number of international activity units contained, where 1 IU is the amount of activity of the procoagulant present in 1 mL of normal plasma.
How are factor concentrates stored?
General Information. Clotting factor concentrates are stored in blood bank between 20C & 80C and should not be stored in ward fridges. Occasionally there are slightly more/less units in the vial e.g. a 500 unit vial may have 513 units or 489 units.
Why do we give factor concentrates?
If a person with a bleeding disorder is missing a factor protein in his or her blood, the obvious treatment is to put back what is missing. This treatment became available in the early 1970s. Drug companies take plasma from blood donors and remove the clotting factor proteins.
What is factor IX concentrate?
What is this medicine? FACTOR IX (fak tir nine) is used in patients with hemophilia B to help control bleeding. Some products may also be used to control bleeding in patients with other disorders that prevent the blood from clotting properly.
What is Factor VII used for?
Factor VIIa is a man-made protein produced to replicate the naturally occurring activated factor VII (factor VIIa) in the body. It is used to stop bleeding of injuries for patients with hemophilia by helping the blood to clot. Factor VIIa is to be given only by or under the direct supervision of your doctor.
What Is factor VIII and factor IX?
Factor VIII, with factor IX, is involved in the creation of a “net” that closes a torn blood vessel. An abnormal gene can make some kids not have enough factor VIII, causing the bleeding disorder known as hemophilia A. Not having enough factor IX is known as hemophilia B.
Is factor 7 present in serum?
Factor VII is a stable, extrinsic coagulation factor that is apparently not required for intrinsic coagulation; it is present in both plasma and serum in trace amounts (0.01 μg/ml).
What is the factor 11?
Factor XI is one of the essential blood proteins and plays a role in aiding the blood to clot. Mutations of the F11 gene result in deficient levels of functional factor XI. The symptoms of factor XI deficiency occur, in part, due to this deficiency.
What is the function of factor IX?
Factor IX is a protein produced naturally in the body. It helps the blood form clots to stop bleeding. Injections of factor IX are used to treat hemophilia B, which is sometimes called Christmas disease.
Where is Factor 9 synthesized?
Factor IX is synthesized in the liver and is subject to a number of posttranslational modifications including gamma-carboxylation, beta-hydroxylation, and glycosylation.
What is a factor 12?
The factors of 12 are the numbers that divide 12 exactly without leaving any remainder. As 12 is an even composite number, it has many factors other than 1 and 12. The factors of 12 can be positive or negative. Hence, the factors of 12 are 1, 2, 3, 4, 6 and 12.