Table of Contents
What is oxidative N-Dealkylation mechanism?
N-oxidation are generally believed to involve transfer of an electron (SET) from the lone pair on the nitrogen to the perferryl species to generate compound II followed by oxygen recombination to give the N-oxide product. N-dealkylation is a major metabolism pathway for many amine drugs.
What does N-Dealkylation do?
N-Dealkylation is a frequently encountered metabolic reaction. It is often responsible for the production of the major metabolite obtained from an N-alkyl containing drug.
What is Dealkylation process?
noun, plural: dealkylations. The removing of alkyl groups from a compound, mainly for altering chemical reactions in organic chemistry. Supplement. This is done by using various oxides, specifically in oxidative dealkylation.
What is the final metabolite of alicyclic N-Dealkylation?
The process generates formic acid and the catechol metabolite 54 as final products.
What are the two phases of drug metabolism?
Metabolism is often divided into two phases of biochemical reaction – phase 1 and phase 2. Some drugs may undergo just phase 1 or just phase 2 metabolism, but more often, the drug will undergo phase 1 and then phase 2 sequentially.
What type of reaction is Dealkylation?
Which of the following are drug metabolism mechanism?
Most drugs must pass through the liver, which is the primary site for drug metabolism. Once in the liver, enzymes convert prodrugs to active metabolites or convert active drugs to inactive forms. The liver’s primary mechanism for metabolizing drugs is via a specific group of cytochrome P-450 enzymes.
Which enzyme is important in the phase 2?
Phase II drug metabolising enzymes are mainly transferases. This review covers the major phase II enzymes: UDP-glucuronosyltransferases, sulfotransferases, N-acetyltransferases, glutathione S-transferases and methyltransferases (mainly thiopurine S-methyl transferase and catechol O-methyl transferase).
What are the three phases of metabolism?
The metabolism of xenobiotics is often divided into three phases:- modification, conjugation, and excretion.