What is plicamycin used for?
Plicamycin, which was formerly known as mithramycin, is an antibiotic that is used as an anticancer agent in the therapy of testicular and germ cell cancers. Plicamycin causes acute hepatic injury that arises within days of starting therapy, but is usually transient and asymptomatic and rarely leads to jaundice.
Is plicamycin available?
Plicamycin is an antineoplastic antibiotic produced by Streptomyces plicatus. It has been used in the treatment of testicular cancer, Paget’s disease of bone, and, rarely, the management of hypercalcemia. The manufacturer discontinued plicamycin in 2000.
Is Mithramycin an antibiotic?
Mithramycin binds to DNA and prevents cells from making RNA and proteins. It is a type of antineoplastic antibiotic. Also called Mithracin and plicamycin.
What are the side effects of calcitonin?
Side Effects
- Blurred vision.
- chills or fever.
- difficulty with breathing.
- difficulty with swallowing.
- frequent urination.
- joint pain.
- muscle aches and pains.
- muscle cramps in the hands, arms, feet, legs, or face.
Who should not take calcitonin?
Has not been shown to increase bone mineral density in early postmenopausal women, which is why use is restricted to women who are at least five years postmenopausal. It should never be used in women with reproductive potential.
What happens with too much calcitonin?
While the excess calcitonin doesn’t affect your body, MTC can, and frequently does, spread to other tissues (metastasizes), especially lymph nodes. C-cell hyperplasia: This is a benign (noncancerous) condition that causes abnormal growth of C-cells in your thyroid. The enlarged tissue can release excess calcitonin.
How do you give calcitonin for hypercalcemia?
Calcitonin — Calcitonin should be administered intramuscularly or subcutaneously; nasal administration of calcitonin is not efficacious for treatment of hypercalcemia [10]. The initial dose is 4 units/kg. The serum calcium is repeated in four to six hours.
How much Plicamycin should I take for hypercalciuria?
In hypercalciuria associated with advanced malignancy the recommended course of treatment with plicamycin is 25 mcg (0.025 mg) per kilogram of body weight per day for 3 or 4 days.
What is Plicamycin used to treat?
Plicamycin is used to treat cancer of the testicles. Plicamycin is also used in the treatment of treat too much calcium in the blood (hypercalcemia) and too much calcium in the urine (hypercalciuria) associated with a variety of advanced forms of cancer. Plicamycin may also be used for purposes other than those listed in this medication guide.
Can Mithracin (Plicamycin) be used for testicular cancer?
Mithracin (plicamycin) may be useful in the treatment of patients with testicular tumors which are resistant to other chemotherapeutic agents. Prior radiation therapy or prior chemotherapy did not alter the response rate with Mithracin (plicamycin) .
What are the side effects of Mithracin (Plicamycin)?
The most common side effects reported with the use of Mithracin (plicamycin) consist of gastrointestinal symptoms: anorexia, nausea, vomiting, diarrhea, and stomatitis. Other less frequently reported side effects include fever, drowsiness, weakness, lethargy, malaise, headache, depression, phlebitis, facial flushing, and skin rash.