Table of Contents
How does UIP differ from NSIP?
NSIP is temporally and spatially homogeneous, while UIP is typically heterogeneous, patchy, and irregular in size. The extent of honeycombing and traction bronchiectasis is greater in UIP than the extent of ground glass opacity or micronodules, which are more commonly associated with an NSIP pattern.
What is UIP pattern on chest CT?
Usual interstitial pneumonia (UIP) is a histopathologic and radiologic pattern of interstitial lung disease, which is the hallmark pattern for idiopathic pulmonary fibrosis (IPF).
What is UIP pattern of interstitial lung disease?
Microscopic Findings. The histopathologic hallmark of usual interstitial pneumonia (UIP) is a low magnification appearance of the patchy dense fibrosis causing remodeling of lung architecture, often resulting in honeycomb change and alternates with areas of less affected parenchyma (see the image below).
What is NSIP?
Nonspecific interstitial pneumonia (NSIP) is one class of idiopathic interstitial pneumonia (IIP). NSIP is chronic interstitial pneumonia with the homogeneous appearance of interstitial fibrosis and inflammation. It is nonspecific as it lacks the histopathological features of the other subtypes of the IIP.
Is NSIP the same as IPF?
The clinical presentation of fibrotic NSIP (cellular NSIP is very uncommon) is similar to IPF, although the patients tend to be women and younger in age. 3 Most cases with the histopathological pattern of NSIP are of unknown aetiology.
Is NSIP curable?
Both inflammation and fibrosis may be present at the same time. Generally, the prognosis is better for patients with the cellular form of NSIP as inflammation is often reversible but fibrosis is permanent.
Is NSIP pulmonary fibrosis?
“Pulmonary fibrosis” (PF) is used to refer to any type of ILD in which fibrosis (also known as scarring) is present, and since most forms of ILD include fibrosis, most forms of ILD are also forms of PF. Idiopathic NSIP is one type of ILD.
Is there an HRCT diagnostic criteria for usual interstitial pneumonia (UIP)?
In 2018, the Fleischner Societyhas also published a white paper on the approach for the HRCT diagnosis of usual interstitial pneumonia: diagnostic HRCT criteria for usual interstitial pneumonia (UIP) pattern – Fleischner society guideline (2018). On this page: Article: Overview Classification
Is UIP pattern indeterminate for UIP diagnosis?
probable UIP pattern indeterminate for UIP pattern alternative diagnosis This helps radiologists to determine the certainty of usual interstitial pneumonia (UIP) diagnosis based on HRCT chest findings. The importance of this guideline is that (definite) UIP pattern on chest HRCT precludes the need for tissue diagnosis 1,2,5.
How should the patient’s management of upper respiratory infection (UIP) be managed?
now, the patient’s management should be based on their HRCT classification in two groups 5: HRCT pattern of probable UIP, indeterminate for UIP, and alternative diagnosis HRCT pattern of UIP See also ATS criteria for the diagnosis of UIP on pathology diagnostic categories of UIP pattern based on HRCT chest- Fleischner society guideline 2018
What is the importance of UIP pattern on chest HRCT?
The importance of this guideline is that (definite) UIP pattern on chest HRCT precludes the need for tissue diagnosis 1,2,5. However, unfortunately up to 20% of inconsistent with UIP group (or actually atypical UIP) can be UIP on biopsy or progress clinically to a diagnosis idiopathic pulmonary fibrosis (IPF). UIP pattern