Table of Contents
What is cholinergic pruritus?
Cholinergic pruritus in human beings is a variant of the more common syndrome, cholinergic urticaria, which is characterized by intense pruritus and pinpoint urticaria. With cholinergic pruritus, intense itching results without urticaria. Specific diagnostic laboratory tests have not been developed.
Why is it called cholinergic urticaria?
Cholinergic urticaria was first described by Duke in 1924 as “urticaria calorica”. The term cholinergic is derived from the finding that hives similar to those of CU can be evoked using cholinergic agonists (e.g. methacholine).
What causes cholinergic hives?
Cholinergic urticaria (CU) is a type of hives brought on by raised body temperature. It typically develops when you exercise or sweat. More often than not, CU appears and disappears on its own within a few hours. In severe cases, CU can sometimes be related to exercise-induced anaphylaxis.
What is cholinergic syndrome?
Acute cholinergic syndrome includes signs and symptoms caused by the stimulation of muscarinic and nicotinic receptors. This may be due to excess acetylcholine caused by the inhibition of enzymes like acetylcholinesterase (AChE), which degrades acetylcholine, or due to exogenous parasympathetic stimulants.
How do you know if you have cholinergic urticaria?
Cholinergic Urticaria Symptoms. These hives are itchy, tingly, and warm. They’re usually small (1-3 millimeter) red bumps with flares or circles around them called wheals. You can get them anywhere on your body, but most of the time they show up on your chest, face, upper back, and arms.
Is cholinergic urticaria and autoimmune disease?
The urticaria is “autoimmune”. The immune system is attacking the normal tissues of the body and causing hives as a result.
What causes a cholinergic effect?
Cholinergic toxicity is caused by substances that stimulate, enhance or mimic the neurotransmitter acetylcholine, the primary neurotransmitter of the parasympathetic nervous systems. Acetylcholine stimulates muscarinic and nicotinic receptors to cause muscle contraction and glandular secretions.
How do you get rid of cholinergic urticaria?
Traditional treatment options for cholinergic urticaria are antihistamines, leukotriene inhibitors, and immunosuppressives. However, cholinergic urticaria in some patients may be refractory. Sometimes, an attack of cholinergic urticaria can be aborted by rapid cooling.
Can stress cause cholinergic urticaria?
Common causes of cholinergic urticaria include increase in body temperature (e.g., following a hot bath or shower), emotional stress, exercise, or consumption of spicy food (Fig.
What are examples of cholinergic drugs?
These include reversible agents (physostigmine, neostigmine, pyridostigmine, edrophonium, rivastigmine, donepezil, galantamine) and irreversible agents (echothiophate, parathion, malathion, diazinon, sarin, soman).
What is Cholestatic pruritus?
Overview of cholestatic pruritus. Cholestasis means “the slowing or stopping of bile flow” which can be caused by any number of diseases of the liver (which produces the bile), the gallbladder (which stores the bile), or biliary tract (also known as the biliary tree, the conduit that allows the bile to leave the liver and gallbladder…
What is the meaning of pruritus?
an unpleasant sensation of the skin, provoking the desire to scratch or rub it; called also itching. adj., adj prurit´ic. It is common in many types of skin disorders, especially allergic inflammation and parasitic infestations. Systemic diseases that may cause pruritus include diabetes mellitus (pruritus vulvae) and liver disorders with jaundice.
What are the systemic disorders associated with pruritus?
Systemic disorders associated with pruritus include uremic pruritus, hepatobiliary pruritus, pruritus due to hematological causes such as polycythemia vera, leukemia, lymphomas (especially Hodgkin’s disease), multiple myeloma, pruritus due to endocrine disorders, and multiple sclerosis.
What is the medical term for itching of the skin?
[proo-ri´tus] an unpleasant sensation of the skin, provoking the desire to scratch or rub it; called also itching. adj., adjprurit´ic. It is common in many types of skin disorders, especially allergic inflammation and parasitic infestations.