Table of Contents
What is the serous of endometrium?
According to their model, endometrial serous carcinoma arises predominantly in the resting endometrium, manifesting first as p53 immunoreactive, morphologically normal endometrial cells, evolving to endometrial glandular dysplasia, then to serous endometrial intraepithelial carcinoma (EIC), and finally into fully …
Can serous uterine cancer be cured?
The definitive treatment for serous endometrial cancer is hysterectomy with bilateral salpingo-oophorectomy and surgical staging [2,4], which typically includes omentectomy and pelvic and para-aortic lymphadenectomy.
Do endometrial cells mean cancer?
Endometrial cancer is a type of cancer that starts in the lining of the uterus, called endometrium. It happens when cells in the endometrium grow out of control and crowd out normal cells. Endometrial cancer cells can spread to other parts of the body such as the vagina or liver and grow there.
What does uterine Serosa mean?
The serosa is the layer of tissue coating the outside of the uterus. In the middle is a thick layer of muscle known as the myometrium. This muscle layer is needed to push a baby out during childbirth.
How fast does serous carcinoma grow?
Recent studies have shown that high-grade serous carcinomas that begin with a primary tumor in the fallopian tubes take an average of 6.5 years to reach the ovaries, after which they spread to other areas quite quickly.
How serious is serous cancer?
Uterine serous carcinoma (USC) accounts for 10% of all endometrial cancer; however, it carries the poorest prognosis, with 5-year survival rates as low as 55% [13].
What causes uterine serous cancer?
Specific risk factors for uterine serous carcinoma include a personal history of breast cancer, tamoxifen exposure, and hereditary cancer syndromes. Common clinical features include older age and higher stage at diagnosis, and mutations in p53.
What is the function of the serosa?
In anatomy, serous membrane (or serosa) is a smooth tissue membrane of mesothelium lining the contents and inner walls of body cavities, which secrete serous fluid to allow lubricated sliding movements between opposing surfaces.
How serious is serous carcinoma?
USC is the most aggressive endometrial cancer, representing less than 10% of all cases, a disproportionate number of deaths and a poor 5-year overall survival of 55%. With such a dismal prognosis, these patients should be treated aggressively. Patients should receive complete surgical staging.
Where does uterine serous carcinoma spread?
Background: Uterine papillary serous carcinoma (UPSC) is a highly malignant form of endometrial cancer with a high propensity for metastases and recurrences even when there is minimal or no myometrial invasion. It usually metastasizes to the pelvis, retroperitoneal lymph nodes, upper abdomen, and peritoneum.
What is the treatment for serous carcinoma?
Treatment for uterine papillary serous carcinoma generally involves surgery, followed by radiation and chemotherapy. Most often, surgery includes removal of the uterus (hysterectomy), fallopian tubes and ovaries, as well as any other cancer that may be visible in the abdomen during surgery.
What does serous mean in cancer?
“Serous” means that the tumor arose from the serous membrane, in the epithelial layer in the abdominopelvic cavity.
Is serous cancerous?
Uterine serous carcinoma (USC) is an aggressive variant of endometrial cancer that has not been well characterized. It accounts for less than 10% of all endometrial cancers and 80% of endometrial cancer–related deaths.
What is uterine serous carcinoma (USC)?
Go to: Abstract Uterine serous carcinoma (USC) is a highly aggressive variant of endometrial cancer. Although it only represents less than 10% of all cases, it accounts for a disproportionate number of deaths from endometrial cancer.
What is serous endometrial cancer?
Serous endometrial cancer represents a relative rare entity accounting for about 10% of all diagnosed endometrial cancer, but it is responsible for 40% of endometrial cancer-related deaths.
What is uterine papillary serous and clear cell cancer?
Uterine papillary serous and clear cell cancer INTRODUCTION— The uterine papillary serous (UPSC) and clear cell types of endometrial cancer, which account for less than 15 percent of all endometrial cancers, are biologically more aggressive than usual endometrioid cancers.
What is the prognosis of uterine serous carcinoma?
Uterine serous carcinoma (USC) accounts for 10% of all endometrial cancer; however, it carries the poorest prognosis, with 5-year survival rates as low as 55% [13]. Go to: Current standard of care