What does it mean if reticulocyte hemoglobin is high?
A higher than normal reticulocytes count may indicate: Anemia due to red blood cells being destroyed earlier than normal (hemolytic anemia) Bleeding. Blood disorder in a fetus or newborn (erythroblastosis fetalis)
What is CHr in hematology?
Reticulocyte hemoglobin content (CHr): early indicator of iron deficiency and response to therapy [letter] | Blood | American Society of Hematology.
What is reticulocyte hemoglobin?
Reticulocytes are the youngest erythrocytes released from the bone marrow into the blood and they circulate for 1-2 days before becoming mature erythrocytes. The reticulocytes’ hemoglobin content reflects the amount of iron available for hemoglobin production in the bone marrow.
What does it mean if your reticulocyte count is low?
If your results show a lower than normal amount of reticulocytes, it may mean you have: Iron deficiency anemia, a type of anemia that happens when you don’t have enough iron in your body.
What can cause a high reticulocyte count?
The reticulocyte count rises when there is a lot of blood loss or in certain diseases in which red blood cells are destroyed prematurely, such as hemolytic anemia. Also, being at high altitudes may cause reticulocyte counts to rise, to help you adjust to the lower oxygen levels at high altitudes.
How is CHr measured?
CHr is measured in the stained reticulocytes using two-angle light scatter and Ret-He is a measure of the forward scatter of stained reticulocytes and has a curvilinear relationship with CHr.
What is a normal absolute reticulocyte count?
The normal reticulocyte count is 0.5-2.5% and the normal absolute reticulocyte count is 50-100X109/L [4–6]. ARC may be very helpful in initial evaluation of pancytopenia but its utility value is often underestimated.
What does a high RET-he mean?
RET-He is used for monitoring erythropoietin (EPO) and/or IV iron therapy. If the value increases it indicates the therapy is having a positive effect.
What conditions can cause a low reticulocyte count?
A lower than normal reticulocyte count may be a sign of several conditions, including hypoproliferative anemias. Hypoproliferative anemias happen when your bone marrow can’t make enough new red blood cells.
What is normal range of reticulocyte count?
Normal Results A normal result for healthy adults who are not anemic is around 0.5% to 2.5%. The normal range depends on your level of hemoglobin. Hemoglobin is a protein in red blood cells that carries oxygen. The range is higher if hemoglobin is low, from bleeding or if red cells are destroyed.
How do you measure reticulocyte hemoglobin?
RET-He is measured on the basis of automated fluorescent flow cytometry which in the reticulocyte channel, using a polymethine dye, also measures the mean value of the forward light scatter intensity of mature red blood cells and reticulocytes. These values equate with reticulocyte hemoglobin content.
What is CHr iron?
CHr is a good indication of iron availability and an early marker of iron deficient erythropoiesis which can be obtained readily using automated blood cell analyzers.
What causes high reticulocyte?
What does a high RET he mean?