Table of Contents
What is Organoid pattern?
The organoid pattern, as defined in this study, is a char- acteristic histologic feature of a meshwork of thin fibrovascu- lar septa surrounding individual small nests of tumor cells in a regular arrangement.
What is histologic pattern?
Histological patterns and/or subpatterns are characteristic of particular tumors or group of tumors; hence for the histopathological diagnosis, these particular patterns are important.
Can spindle cells be benign?
Spindle cell lesions of the breast constitute a wide spectrum of benign and malignant proliferations.
What is bland spindle cell proliferation?
Bland-looking spindle cell lesions of the breast comprise a heterogeneous group of tumor-like and tumor entities, ranging from reactive to low-grade malignant neoplasms with metastatic potential 1.
What is organoid culture?
Organoid culture is a tissue culture method to grow functional 3D organoids from a group of cells and combination of various biochemical factors.
What is staghorn pattern?
The staghorn pattern of vascularity is a pathological term describing a pattern of vascularity seen on low-power light microscopy. It is defined by multiple thin-walled, sharply-branched and jagged vessels having an “antler-like” or “staghorn-like” appearance 1.
Are all spindle cells cancerous?
Spindle cell lesions of the head and neck are quite diverse with great clinical and biological heterogeneity. Some are malignant while many others are benign or simply reactive in nature.
Are spindle cells cancerous?
What is spindle cell sarcoma? Spindle cell sarcoma is a rare malignant (cancerous) tumour which can develop in the bone or soft tissue. It can arise in any part of the body but is most common in the limbs (arms and legs).
What is a 3D organoid?
Organoids are three-dimensional (3D) cell structures grown in vitro from stem cells, primarily isolated either from biopsies or from pluripotent stem cells, that recapitulate key features of both the development and performance of native organs [1].
How do you classify a tumor?
Tumors are traditionally classified four ways: (I) broadly, by tissue, organ, and system; then by (II) specific type, and (III) grade according to WHO classifications; and (IV) finally by spread according to the Tumor Node Metastasis (TNM) system.
What is abnormal tissue growth?
A tumor is an abnormal growth of body tissue. Tumors can be cancerous (malignant) or noncancerous (benign).
What is a spindle tumor?
(SPIN-dul sel TOO-mer) A type of tumor that contains cells called spindle cells, based on their shape. Under a microscope, spindle cells look long and slender. Spindle cell tumors may be sarcomas or carcinomas.
What is the treatment for spindle cell sarcoma?
Chemotherapy. The first round of chemotherapy is administered before any surgery to help shrink the primary tumor and kill any cancer cells that may have spread throughout the body. Generally, this treatment uses 3 different chemotherapy drugs over the course of 10 weeks.