Table of Contents
Does phenolphthalein cause cancer?
It is more likely that the multiple biological properties of phenolphthalein, including its ability to form free radicals, its clastogenic activity, and its estrogenic activity, contributed to the carcinogenic effects observed. These studies show that phenolphthalein is a multisite/multispecies carcinogen.
Is phenolphthalein used as a laxative?
Background: Phenolphthalein is widely used as a safe and effective laxative. After oral administration, phenolphthalein is absorbed in the small bowel and is conjugated in the liver to phenolphthalein glucuronide which passes into the colon where it is deconjugated and the active compound, phenolphthalein, is released.
Does phenolphthalein cause genetic defects?
In a study of 236 newborns exposed to phenolphthalein during the first trimester, no increased risk for congenital defects was found [37].
Does phenolphthalein cause diarrhea?
It causes stool evacuation by enhancing fluid and electrolyte accumulation in the intestines. After ingestion, phenolphthalein is excreted in both the feces and the urine and is detectable for up to 32 hours. It may also have laxative effects for up to 4 days and cause fluid and electrolyte abnormalities.
What happens if I swallow phenolphthalein?
Ingestion: Harmful if swallowed. May cause irritation of the digestive tract. Ingestion may cause fever, blood pressure increase and other unspecified vascular effects. Inhalation: May cause respiratory tract irritation.
Is phenolphthalein toxic in contact with skin?
Use only in well ventilated areas.Do not eat, drink, smoke, or use personal products when handling chemical substances. Wash hands before breaks and immediately after handling the product. Avoid contact with skin, eyes, and clothing. Empty containers retain product residue and can be dangerous.
Is phenolphthalein environmentally friendly?
Phenolphthalein content is potentially carcinogenic and mutagenic. Environmental The product is not classed as environmentally hazardous. The product is miscible with water and will spread in water systems.
What happens if you inhale phenolphthalein?
Ingestion may cause fever, blood pressure increase and other unspecified vascular effects. Inhalation: May cause respiratory tract irritation. May be harmful if inhaled.
What is phenolphthalein used for medical?
Medical uses. Despite concerns regarding its carcinogenicity, the use of phenolphthalein as a laxative is unlikely to cause ovarian cancer. Phenolphthalein has been found to inhibit human cellular calcium influx via store-operated calcium entry (SOCE, see Calcium release activated channel ยง Structure ).
Does phenolphthalein cause ovarian cancer?
Phenolphthalein is believed to be carcinogenic in nature. Facing concerns about its carcinogenicity, it is doubtful that the use of phenolphthalein as a laxative would induce ovarian cancer via SOCE (Calcium release-activated channel and Structure), it has been found to inhibit human cellular calcium influx.
Is phenolphthalein toxic to humans?
Toxic Effects Phenolphthalein has been observed to cause cancers in animals, based on studies. This has raised suspicions over the use of phenolphthalein by humans. However, studies have also shown that phenolphthalein does not increase the risk of getting cancers such as kidney cancer, lymphoma and kidney cancer.
What is the structure of phenolphthalein?
Phenolphthalein acts as an indicator in acid-base titrations. There are three hexagonal structures and one pentagonal structure, two alcoholic groups, and one ketone group in the structure of Phenolphthalein. Also, the carbon, hydrogen, and oxygen chains form the Phenolphthalein structure.