What are the contraindications of dinoprostone?
Dinoprostone Vaginal Insert is contraindicated in:
- Patients with known hypersensitivity to prostaglandins.
- Patients in whom there is clinical suspicion or definite evidence of fetal distress where delivery is not imminent.
- Patients with unexplained vaginal bleeding during this pregnancy.
What are the side effects of dinoprostone?
Side Effects
- Fast or slow heartbeat.
- hives.
- increased pain of the uterus.
- pale, cool, blotchy skin on arms or legs.
- pressing or painful feeling in chest.
- shortness of breath.
- swelling of face, inside the nose, and eyelids.
- tightness in chest.
Is prostaglandin contraindicated in pregnancy?
Prostaglandin E2 (PGE2) is used to induce labor and should not be used in people that are contraindicated to give birth vaginally or spontaneous labor. PGE2 should not be used in people with allergies to prostaglandins or any components in the drugs formulations.
What are the contraindications of prostaglandin?
One major contraindication to prostaglandin therapy is hypersensitivity to the drug. The use of misoprostol for gastric ulcer treatment is contraindicated in prepartum pregnant patients because misoprostol causes cervical ripening and can induce abortion.
What is the purpose of dinoprostone gel?
Dinoprostone is used to prepare the cervix for the induction of labor in pregnant women who are at or near term.
Which prostaglandin causes fever?
The appearance of fever is associated with the release in the hypothalamus of a lipid compound called prostaglandin E2 (PGE2), which has an important role in the regulation of body temperature.
Which prostaglandins cause fever and pain?
Do prostaglandins increase temperature?
The experiments on the effects of PGE1 and PGE2 show quite clearly that prostaglandins raise body temperature by a coordinated increase in heat production and a decrease in heat loss.
Are prostaglandins contraindicated in asthma?
Prostaglandin E2 (Prostin E2®) and Prostaglandin PGE1 (Cytotec®) can be used in pregnant patients with asthma, if obstetrically indicated. Prostaglandin F2∝ (Hemabate®) is a potent bronchoconstrictor and should probably not be used in pregnant patients with asthma.
How often can dinoprostone gel be administered?
If there is no cervical/uterine response to the initial dose, a repeat dose may be given (0.5 mg gel every 6 hours). Max cumulative dose: 1.5 mg (7.5 mL of gel) per 24-hour period. One 10 mg vaginal insert administered high into the vagina and placed transversely in the posterior fornix.
How long does dinoprostone gel take to work?
It takes 30 to 40 minutes for the insert to swell. It may fall out if you stand up too soon, so you’ll need to stay in bed for 1 hour. The nurse will check you often during this hour. After the first hour, the checks may stop.
How often can Dinoprostone gel be administered?
How long does Dinoprostone gel take to work?
Do prostaglandins cause inflammation?
Prostaglandins play a key role in the generation of the inflammatory response. Their biosynthesis is significantly increased in inflamed tissue and they contribute to the development of the cardinal signs of acute inflammation.