Table of Contents
How does chloramphenicol work on bacteria?
Chloramphenicol stops bacterial growth by binding to the bacterial ribosome (blocking peptidyl transferase) and inhibiting protein synthesis. Chloramphenicol is lipid-soluble, allowing it to diffuse through the bacterial cell membrane.
What is chloramphenicol and how does it work?
Chloramphenicol is used in the treatment of infections caused by bacteria. It works by killing bacteria or preventing their growth.
What is the mode of action of chloramphenicol Mcq?
Explanation: Chloramphenicol inhibits protein synthesis by combining with the 50S subunit ribosome. The transpeptidation and translocation functions associated with this site are blocked.
How does chloramphenicol work a level biology?
Chloramphenicol diffuses through the bacterial cell wall and reversibly binds to the bacterial 50S ribosomal subunit. The binding interferes with peptidyl transferase activity, thereby prevents transfer of amino acids to the growing peptide chains and blocks peptide bond formation.
How chloramphenicol inhibits protein synthesis?
Chloramphenicol inhibits microbial protein synthesis by binding to the 50 S subunit of the 70 S ribosome and inhibiting the action of peptidyl transferase, thus preventing peptide bond formation. This mechanism also prevents the binding of aminoacyl transfer RNA to the peptidyl transferase active site.
What class of antibiotic is chloramphenicol?
Chloramphenicol is an antibiotic and is in the class of antimicrobials that inhibits protein synthesis.
What class of drug is chloramphenicol?
Which type of drug is chloramphenicol?
Chloramphenicol is a medication used in the management and treatment of superficial eye infections such as bacterial conjunctivitis, and otitis externa. It has also been used for the treatment of typhoid and cholera. Chloramphenicol is an antibiotic and is in the class of antimicrobials that inhibits protein synthesis.
How does chloramphenicol inhibit translation?
Chloramphenicol is a broad-spectrum antibiotic targeting the protein synthesis machinery by binding to the bacterial ribosome. Chloramphenicol has been considered a classic general inhibitor of translation, blocking the accommodation of aa-tRNA into the A site of the large ribosomal subunit.
What does chloramphenicol do to ribosomes?
Chloramphenicol inhibits peptide bond formation by preventing the aminoacyl-tRNA 3′ end from binding in the peptidyl transferase center (47), whereas erythromycin hampers the progression of the nascent peptide chain through the ribosomal exit tunnel (34, 55, 58).
What is the indication of chloramphenicol?
How does chloramphenicol stop protein synthesis?
What inhibitors have bacteriostatic action?
[1][2][3][4] The following classes and specific antimicrobials are generally bacteriostatic: tetracyclines, macrolides, clindamycin, trimethoprim/sulfamethoxazole, linezolid, and chloramphenicol.
How Chloramphenicol inhibits protein synthesis?
What is the contraindication for chloramphenicol?
Chloramphenicol is contraindicated in individuals with a history of previous hypersensitivity and/or toxic reaction to it. It must not be used in the treatment of trivial infections or where it is not indicated, as in colds, influenza, infections of the throat.
Is chloramphenicol bactericidal or bacteriostatic?
Chloramphenicol is bactericidal at clinically achievable concentrations against Haemophilus influenzae, Streptococcus pneumoniae, and Neisseria meningitidis. It is bacteriostatic against gram-negative bacilli of the family Enterobacteriaceae and against Staphylococcus aureus.
Is chloramphenicol bacteriostatic or bactericidal?
What is the mode of action of chloramphenicol?
BARNUM CP,NASH CW,et al.
What are risks of contact and inhalation of chloramphenicol?
case reports implicating chloramphenicol as a cause of aplastic anemia, the evidence of a link between aplastic anemia and leukemia, and the increased risk of leukemia found in some case-control studies support the conclusion that an increased cancer risk is associated with chloramphenicol exposure. Children may be a particularly susceptible
How good is chloramphenicol?
Chloramphenicol is safe for most adults and children.
How to say chloramphenicol?
How to say chloramphenicol in English? Pronunciation of chloramphenicol with 3 audio pronunciations, 2 synonyms, 2 meanings, 10 translations, 4 sentences and more for chloramphenicol.